Treatment of large bone defects in load-bearing bone: traditional and novel bone grafts.

IF 4.9 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Dan Yu, Wenyi Shen, Jiahui Dai, Huiyong Zhu
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引用次数: 0

Abstract

Large bone defects in load-bearing bone can result from tumor resection, osteomyelitis, trauma, and other factors. Although bone has the intrinsic potential to self-repair and regenerate, the repair of large bone defects which exceed a certain critical size remains a substantial clinical challenge. Traditionally, repair methods involve using autologous or allogeneic bone tissue to replace the lost bone tissue at defect sites, and autogenous bone grafting remains the "gold standard" treatment. However, the application of traditional bone grafts is limited by drawbacks such as the quantity of extractable bone, donor-site morbidities, and the risk of rejection. In recent years, the clinical demand for alternatives to traditional bone grafts has promoted the development of novel bone-grafting substitutes. In addition to osteoconductivity and osteoinductivity, optimal mechanical properties have recently been the focus of efforts to improve the treatment success of novel bone-grafting alternatives in load-bearing bone defects, but most biomaterial synthetic scaffolds cannot provide sufficient mechanical strength. A fundamental challenge is to find an appropriate balance between mechanical and tissue-regeneration requirements. In this review, the use of traditional bone grafts in load-bearing bone defects, as well as their advantages and disadvantages, is summarized and reviewed. Furthermore, we highlight recent development strategies for novel bone grafts appropriate for load-bearing bone defects based on substance, structural, and functional bionics to provide ideas and directions for future research.

承重骨大骨缺损的治疗:传统骨移植与新型骨移植。
承重骨的大骨缺损可由肿瘤切除、骨髓炎、创伤和其他因素引起。尽管骨具有自我修复和再生的内在潜力,但超过一定临界尺寸的骨缺损的修复仍然是一个重大的临床挑战。传统上,修复方法包括使用自体或异体骨组织替换缺损部位丢失的骨组织,自体骨移植仍然是“金标准”治疗方法。然而,传统骨移植的应用受到诸如可提取骨的数量、供体部位发病率和排斥风险等缺点的限制。近年来,临床对传统骨移植替代品的需求促进了新型骨移植替代品的发展。除了骨导电性和骨诱导性外,最佳的力学性能最近成为提高新型骨移植替代品在承重骨缺陷治疗成功率的重点,但大多数生物材料合成支架不能提供足够的机械强度。一个基本的挑战是在机械和组织再生需求之间找到一个适当的平衡。本文就传统骨移植治疗负重骨缺损的方法及其优缺点作一综述。此外,我们重点介绍了基于物质、结构和功能仿生学的适用于承重骨缺损的新型骨移植物的最新发展策略,为未来的研究提供思路和方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Zhejiang University SCIENCE B
Journal of Zhejiang University SCIENCE B 生物-生化与分子生物学
CiteScore
8.70
自引率
13.70%
发文量
2125
审稿时长
3.0 months
期刊介绍: Journal of Zheijang University SCIENCE B - Biomedicine & Biotechnology is an international journal that aims to present the latest development and achievements in scientific research in China and abroad to the world’s scientific community. JZUS-B covers research in Biomedicine and Biotechnology and Biochemistry and topics related to life science subjects, such as Plant and Animal Sciences, Environment and Resource etc.
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