Emerging in vivo tools for ILC2 research.

IF 12.6 1区医学 Q1 IMMUNOLOGY

Journal of Experimental Medicine Pub Date : 2025-07-07 Epub Date: 2025-05-29 DOI:10.1084/jem.20250883

Timotheus Y F Halim

引用次数: 0

Abstract

ILC2 are critical regulators of inflammation and tissue homeostasis in diverse anatomical sites. ILC2-targeted mouse models have underpinned this emerging field of research. In this issue of JEM, (Kabil et al. https://doi.org/10.1084/jem.20241671) developed a novel Il17rbCreERT2.eGFP mouse to study the role of Rora in mature ILC2.

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新兴的ILC2体内研究工具。

ILC2是不同解剖部位炎症和组织稳态的关键调节因子。靶向ilc2的小鼠模型为这一新兴研究领域奠定了基础。在本期《JEM》中，（Kabil et al. https://doi.org/10.1084/jem.20241671）开发了一种新的Il17rbCreERT2。eGFP小鼠研究Rora在成熟ILC2中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Experimental Medicine 医学-免疫学

CiteScore

26.60

自引率

1.30%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Since its establishment in 1896, the Journal of Experimental Medicine (JEM) has steadfastly pursued the publication of enduring and exceptional studies in medical biology. In an era where numerous publishing groups are introducing specialized journals, we recognize the importance of offering a distinguished platform for studies that seamlessly integrate various disciplines within the pathogenesis field. Our unique editorial system, driven by a commitment to exceptional author service, involves two collaborative groups of editors: professional editors with robust scientific backgrounds and full-time practicing scientists. Each paper undergoes evaluation by at least one editor from both groups before external review. Weekly editorial meetings facilitate comprehensive discussions on papers, incorporating external referee comments, and ensure swift decisions without unnecessary demands for extensive revisions. Encompassing human studies and diverse in vivo experimental models of human disease, our focus within medical biology spans genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We eagerly welcome reports ranging from atomic-level analyses to clinical interventions that unveil new mechanistic insights.