Novel acute kidney injury biomarkers and their utility in children and adolescents-overview.

IF 3.2 3区 医学 Q1 PEDIATRICS
Adrianna Bargielska, Anna Wasilewska, Agnieszka Rybi-Szumińska
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引用次数: 0

Abstract

Acute kidney injury (AKI) affects a significant percentage of the pediatric population. Currently, the diagnosis of AKI in children still uses traditional laboratory methods (ex. creatinine or urea serum concentration and measurement of urine output). It has significant limitations. Early stages of AKI in children may be almost asymptomatic. In-depth assessment with the pRIFLE scale is helpful, but requires bladder catheterization and precise monitoring of hourly diuresis, as well as multiple blood draws to determine changes in creatinine concentration and estimate glomerular filtration rate (eGFR). The diagnostic methods lack a marker that would the early and potentially reversible phase of kidney damage. This paper reviews recent data on selected AKI markers in children, including their diagnostic and prognostic potential.

新的急性肾损伤生物标志物及其在儿童和青少年中的应用综述。
急性肾损伤(AKI)影响儿科人口的显著百分比。目前,儿童AKI的诊断仍采用传统的实验室方法(如血清肌酐或尿素浓度测定及尿量测定)。它有明显的局限性。儿童AKI的早期阶段可能几乎没有症状。用prile量表进行深入评估是有帮助的,但需要膀胱导尿和精确监测每小时利尿,以及多次抽血来确定肌酐浓度的变化和估计肾小球滤过率(eGFR)。这些诊断方法缺乏一种标记物,可以发现肾脏损害的早期和潜在的可逆阶段。本文回顾了儿童AKI标志物的最新数据,包括其诊断和预后潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.10
自引率
13.90%
发文量
192
审稿时长
6-12 weeks
期刊介绍: Italian Journal of Pediatrics is an open access peer-reviewed journal that includes all aspects of pediatric medicine. The journal also covers health service and public health research that addresses primary care issues. The journal provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field. Italian Journal of Pediatrics, which commenced in 1975 as Rivista Italiana di Pediatria, provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field.
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