Association of depressive symptoms, physical function, and cardiovascular disease risk in middle-aged and elderly Chinese.

IF 3.1 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Frontiers in Medicine Pub Date : 2025-05-14 eCollection Date: 2025-01-01 DOI:10.3389/fmed.2025.1513614

Miao Li, Shuo Zhuang, Yan Gao

{"title":"Association of depressive symptoms, physical function, and cardiovascular disease risk in middle-aged and elderly Chinese.","authors":"Miao Li, Shuo Zhuang, Yan Gao","doi":"10.3389/fmed.2025.1513614","DOIUrl":null,"url":null,"abstract":"Objective: Current research suggests that depressive symptoms and physical function increase the risk of developing cardiovascular disease (CVD), but how these factors interact to increase the risk of CVD remains unclear. Therefore, we used data from Chinese middle-aged and older adults to investigate the relationship between depressive symptoms and physical function and CVD risk.Methods: Using information from the China Health and Retirement Longitudinal Study (CHARLS), we examined the relationship between depressive symptoms, physical functioning, and CVD risk in middle-aged and older Chinese adults. The subsequent seven-year endeavor, which ran from 2011 to 2018, enrolled Chinese adults who were middle-aged and older (≥45 years). The exposures of interest were symptoms of depression and physical impairment. To measure depression symptoms, the Center for Epidemiological Studies Depression Scale (CESD-10) was used. The physical disability was ascertained using the physical mobility function. Its principal endpoint was the incidence of CVD. Cox proportional hazards regression methods has been applied to ascertain 95% of the hazard ratios (HRs) and confidence intervals (CIs). Cox multivariate regression and stratified interaction analysis analyses were employed to investigate the association between depressive symptoms, physical functioning, and CVD.Results: A total of 1980 people were included, of whom the mean age of the participants was 56.4 ± 7.7 years, of whom 1,013 (51.2%) were women. During the maximum follow-up period of 7 years, 303 (15.3%) suffered from cardiovascular disease, of whom 246 (12.4%) had heart disease and 72 (3.6%) suffered from stroke. Compared with those with NDS (no depressive symptoms) (CESD <10) and NPD (no physical dysfunction), those with both DS (depressive symptoms) (CESD ≥10) and PD (physical dysfunction) had the highest risk of overall CVD (adjusted hazard ratio [HR], 1.88; 95% CI 1.18 to 3), coronary heart disease (HR, 2.45; 95% CI 1.44 to 4.18) and stroke (HR, 0.45; 95% CI 0.15 to 1.31), which were most common in people aged 60 years or younger.Conclusion: This study found that older adults with DS and PD were strongly associated with an increased risk of CVD.","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1513614"},"PeriodicalIF":3.1000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116637/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fmed.2025.1513614","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Current research suggests that depressive symptoms and physical function increase the risk of developing cardiovascular disease (CVD), but how these factors interact to increase the risk of CVD remains unclear. Therefore, we used data from Chinese middle-aged and older adults to investigate the relationship between depressive symptoms and physical function and CVD risk.

Methods: Using information from the China Health and Retirement Longitudinal Study (CHARLS), we examined the relationship between depressive symptoms, physical functioning, and CVD risk in middle-aged and older Chinese adults. The subsequent seven-year endeavor, which ran from 2011 to 2018, enrolled Chinese adults who were middle-aged and older (≥45 years). The exposures of interest were symptoms of depression and physical impairment. To measure depression symptoms, the Center for Epidemiological Studies Depression Scale (CESD-10) was used. The physical disability was ascertained using the physical mobility function. Its principal endpoint was the incidence of CVD. Cox proportional hazards regression methods has been applied to ascertain 95% of the hazard ratios (HRs) and confidence intervals (CIs). Cox multivariate regression and stratified interaction analysis analyses were employed to investigate the association between depressive symptoms, physical functioning, and CVD.

Results: A total of 1980 people were included, of whom the mean age of the participants was 56.4 ± 7.7 years, of whom 1,013 (51.2%) were women. During the maximum follow-up period of 7 years, 303 (15.3%) suffered from cardiovascular disease, of whom 246 (12.4%) had heart disease and 72 (3.6%) suffered from stroke. Compared with those with NDS (no depressive symptoms) (CESD <10) and NPD (no physical dysfunction), those with both DS (depressive symptoms) (CESD ≥10) and PD (physical dysfunction) had the highest risk of overall CVD (adjusted hazard ratio [HR], 1.88; 95% CI 1.18 to 3), coronary heart disease (HR, 2.45; 95% CI 1.44 to 4.18) and stroke (HR, 0.45; 95% CI 0.15 to 1.31), which were most common in people aged 60 years or younger.

Conclusion: This study found that older adults with DS and PD were strongly associated with an increased risk of CVD.

查看原文本刊更多论文

中国中老年人群抑郁症状、身体功能和心血管疾病风险的相关性

目的：目前的研究表明，抑郁症状和身体功能增加了发生心血管疾病（CVD）的风险，但这些因素如何相互作用以增加CVD的风险尚不清楚。因此，我们使用中国中老年人的数据来调查抑郁症状与身体功能和CVD风险之间的关系。方法：利用中国健康与退休纵向研究（CHARLS）的信息，我们研究了中国中老年成年人抑郁症状、身体功能和心血管疾病风险之间的关系。随后的7年研究从2011年持续到2018年，招募了中老年（≥45 岁）的中国成年人。感兴趣的暴露是抑郁和身体缺陷的症状。采用流行病学研究中心抑郁量表（csd -10）测量抑郁症状。使用肢体活动功能确定肢体残疾。其主要终点是心血管疾病的发病率。采用Cox比例风险回归方法确定95%的风险比（hr）和置信区间（ci）。采用Cox多变量回归和分层相互作用分析来调查抑郁症状、身体功能和CVD之间的关系。结果：共纳入1980人，平均年龄56.4 ± 7.7 岁，其中女性1013人（51.2%）。在最长7 年的随访期间，303人（15.3%）患有心血管疾病，其中246人（12.4%）患有心脏病，72人（3.6%）患有中风。结论：本研究发现，患有DS和PD的老年人与CVD的风险增加密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Medicine Medicine-General Medicine

CiteScore

5.10

自引率

5.10%

发文量

3710

审稿时长

12 weeks

期刊介绍： Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world