Retinal and choroidal blood flow changes in dialysis patients assessed by wide-field swept-source optical coherence tomography angiography.

IF 3.1 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Frontiers in Medicine Pub Date : 2025-05-14 eCollection Date: 2025-01-01 DOI:10.3389/fmed.2025.1524503
Wan Li, Qing Zhou, Jiulin Ni, Xun Pan, Min Li, Fei Hua, Huan Tang, Shuting Li
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Abstract

Purpose: The study utilized wide-field swept-source optical coherence tomography angiography (SS-OCTA) to examine the alterations in retinal and choroidal blood flow in patients with end-stage renal disease (ESRD) before and after hemodialysis.

Methods: Forty-two eyes of 24 participants with end-stage renal disease were enrolled in this prospective and cross-sectional study. A full ophthalmic examination was conducted on each participant 1 h before and after hemodialysis, which included wide-field SS-OCTA imaging on OCTA scans measuring 9 mm x 9 mm. The mean perfusion area (PA), superficial vessel density (SVD), retinal inner VD (RIVD), and choroidal vascularity index (CVI) were evaluated independently before and after hemodialysis in both macular and optic disk areas across all 16 sectors defined by the Early Treatment Diabetic Retinopathy Study (ETDRS).

Results: The study subjects consisted of 18 men and 6 women, comprising 9 patients with diabetic renal failure and 23 patients with hypertension. The mean age of the patients with end-stage renal disease was 57.3 ± 12.7 years. In the central ring, retinal inner VD were significantly decreased after HD (p < 0.05), but there were no significant differences in the average PA,SVD, and CVI between before and after single HD session. In the 3 mm radius, inferior quadrant of macular retinal inner VD, PA of the macular and optic disk were significantly decreased after HD (p < 0.05). In the 6 mm radius, the temporal section of the retinal inner VD, nasal and inferior of PA were noticeably reduced in the HD group. In the wide-field scans (9 mm radius), there was exhibited a more pronounced reduction in inferior PA, SVD and retinal inner VD of optic disk area in inferior sectors after HD. Fairly consistent CVI values were noted in the macular zone, except for a statistically significant decrease in the temporal quadrant at 3 mm and 6 mm within the optic disk area (p = 0.040 and 0.048, respectively).

Conclusion: Results revealed a more significant decrease in indicators of the choroid and optic disk area compared to the inner retina and macular zone. Wide-field SS-OCTA displays potential as an imaging technique for early detection of microcirculation changes in hemodialysis patients.

宽视场扫描源光学相干断层扫描血管造影评估透析患者视网膜和脉络膜血流变化。
目的:本研究利用宽视场扫描源光学相干断层血管造影(SS-OCTA)检查终末期肾病(ESRD)患者血液透析前后视网膜和脉络膜血流的变化。方法:这项前瞻性和横断面研究纳入了24名终末期肾病患者的42只眼睛。每位参与者在血液透析前后1小时进行全面眼科检查,包括在OCTA扫描上进行宽视场SS-OCTA成像,尺寸为9 mm x 9 mm。通过早期治疗糖尿病视网膜病变研究(ETDRS),在血液透析前后分别对黄斑和视盘区域的平均灌注面积(PA)、浅表血管密度(SVD)、视网膜内VD (RIVD)和脉络膜血管指数(CVI)进行独立评估。结果:研究对象男性18例,女性6例,其中糖尿病性肾衰竭患者9例,高血压患者23例。终末期肾病患者的平均年龄为57.3 ± 12.7 岁。在中心环,HD后视网膜内VD显著降低(p p p = 分别为0.040和0.048)。结论:与视网膜内区和黄斑区相比,脉络膜和视盘区各项指标的下降更为明显。宽视场SS-OCTA显示了作为早期检测血液透析患者微循环变化的成像技术的潜力。
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来源期刊
Frontiers in Medicine
Frontiers in Medicine Medicine-General Medicine
CiteScore
5.10
自引率
5.10%
发文量
3710
审稿时长
12 weeks
期刊介绍: Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world
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