{"title":"Prediction of post-Schroth Cobb angle changes in adolescent idiopathic scoliosis patients based on neural networks and surface electromyography.","authors":"Shuguang Yin, Jiangang Chen, Peng Yan","doi":"10.3389/fbioe.2025.1570022","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>To develop a temporal-convolutional-LSTM (TCN-LSTM) hybrid model integrating surface electromyography (sEMG) signals for forecasting post-Schroth Cobb angle progression in adolescent idiopathic scoliosis (AIS) patients, thereby offering accurate feedback for personalized treatment.</p><p><strong>Methodology: </strong>A total of 143 AIS patients were included. A systematic Schroth exercise training program was designed. sEMG data from specific muscles and Cobb angle measurements were collected. A neural network model integrating Temporal Convolutional Network (TCN), Long Short-Term Memory (LSTM) layers, and feature vectors was constructed. Four prediction models were compared: TCN-LSTM hybrid model, TCN, LSTM, and Support Vector Regression (SVR).</p><p><strong>Results: </strong>The TCN-LSTM hybrid model demonstrated superior performance, with Cobb angle-Thoracic (Cobb Angle-T) prediction accuracy reaching R<sup>2</sup> = 0.63 (baseline) and 0.69 (Week 24), achieving overall R<sup>2</sup> = 0.74. For Cobb angle-Lumbar (Cobb Angle-L), accuracy was R<sup>2</sup> = 0.61 (baseline) and 0.65 (Week 24), with overall R<sup>2</sup> = 0.73. The SVR model showed lowest performance (R<sup>2</sup> < 0.12).</p><p><strong>Conclusion: </strong>The TCN-LSTM hybrid model can precisely predict Cobb angle changes in AIS patients during Schroth exercises, especially in long-term predictions. It provides real-time feedback for clinical treatment and contributes to optimizing treatment plans, presenting a novel prediction approach and reference basis for evaluating the effectiveness of Schroth correction exercises in AIS patients.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1570022"},"PeriodicalIF":4.3000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116612/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2025.1570022","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: To develop a temporal-convolutional-LSTM (TCN-LSTM) hybrid model integrating surface electromyography (sEMG) signals for forecasting post-Schroth Cobb angle progression in adolescent idiopathic scoliosis (AIS) patients, thereby offering accurate feedback for personalized treatment.
Methodology: A total of 143 AIS patients were included. A systematic Schroth exercise training program was designed. sEMG data from specific muscles and Cobb angle measurements were collected. A neural network model integrating Temporal Convolutional Network (TCN), Long Short-Term Memory (LSTM) layers, and feature vectors was constructed. Four prediction models were compared: TCN-LSTM hybrid model, TCN, LSTM, and Support Vector Regression (SVR).
Results: The TCN-LSTM hybrid model demonstrated superior performance, with Cobb angle-Thoracic (Cobb Angle-T) prediction accuracy reaching R2 = 0.63 (baseline) and 0.69 (Week 24), achieving overall R2 = 0.74. For Cobb angle-Lumbar (Cobb Angle-L), accuracy was R2 = 0.61 (baseline) and 0.65 (Week 24), with overall R2 = 0.73. The SVR model showed lowest performance (R2 < 0.12).
Conclusion: The TCN-LSTM hybrid model can precisely predict Cobb angle changes in AIS patients during Schroth exercises, especially in long-term predictions. It provides real-time feedback for clinical treatment and contributes to optimizing treatment plans, presenting a novel prediction approach and reference basis for evaluating the effectiveness of Schroth correction exercises in AIS patients.
期刊介绍:
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.