A convergent synthetic approach to the tetracyclic core framework of khayanolide-type limonoids.

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2025-05-12 eCollection Date: 2025-01-01 DOI:10.3762/bjoc.21.75

Zhiyang Zhang, Jialei Hu, Hanfeng Ding, Li Zhang, Peirong Rao

引用次数: 0

Abstract

A convergent approach for the enantioselective construction of an advanced intermediate containing the [5,5,6,6]-tetracyclic core framework of the khayanolide-type limonoids was described. The strategy features an acylative kinetic resolution of the benzylic alcohol, a 1,2-Grignard addition and an AcOH-interrupted Nazarov cyclization.

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khayanolide型柠檬素四环核心骨架的收敛合成方法。

介绍了一种收敛方法，用于对映选择性构建含有[5,5,6,6]-四环核心框架的khayanolide型柠檬素的高级中间体。该策略具有苯基醇的酰化动力学分解，1,2-格氏加成和acoh中断的Nazarov环化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.