Physiologic Consequences of Housing Adult Male Cynomolgus Monkeys (Macaca fascicularis) in Heterosexual Pairs: A Pilot Study Using Implanted Biotelemetry
Rosemary Santos, Dong-Binh Tran, Dingzhou Li, Peter Harris, Jan Bernal, Steven Kreuser, Erin Ricciardi, Siri Skowronek, Kiran Palyada, John P. Capitanio
{"title":"Physiologic Consequences of Housing Adult Male Cynomolgus Monkeys (Macaca fascicularis) in Heterosexual Pairs: A Pilot Study Using Implanted Biotelemetry","authors":"Rosemary Santos, Dong-Binh Tran, Dingzhou Li, Peter Harris, Jan Bernal, Steven Kreuser, Erin Ricciardi, Siri Skowronek, Kiran Palyada, John P. Capitanio","doi":"10.1002/ajp.70052","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Facilities may forgo attempting to socially house adult males due to fear of animal injury, study disruptions, and confounding data results. To leverage the potential advantages of male–female pairs, and to understand the impact on measures typically used in safety pharmacology studies, we measured activity as well as physiologic parameters in vasectomized male-female pairs: heart rate, blood pressure, and body temperature. Seven singly housed males that were previously implanted with telemetry were vasectomized and paired with females. Data were collected before and after pairing at specific timepoints in the first study. A second study employed four nonvasectomized, singly housed males to determine if the physiologic effects observed in the first study could be due simply to the increased cage size due to pairing. Results indicated that pair-housing with a female resulted immediately in a significant increase in blood pressure, body temperature, and heart rate. Over the course of a week of being paired, the males showed a significant decline in blood pressure; body temperature remained elevated, though at a lower level than during the immediate response. The second study suggested that increased cage size alone could not account for the immediate results in Experiment 1, inasmuch as no effects were found on our measures. Although the sample sizes for the studies were small, we discuss how our results are similar to, and differ from, previous studies, as well as the clinical significance and welfare implications. This information may be useful in designing long-term studies using sexually mature males while providing stable social support to animals.</p></div>","PeriodicalId":7662,"journal":{"name":"American Journal of Primatology","volume":"87 6","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Primatology","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ajp.70052","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ZOOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Facilities may forgo attempting to socially house adult males due to fear of animal injury, study disruptions, and confounding data results. To leverage the potential advantages of male–female pairs, and to understand the impact on measures typically used in safety pharmacology studies, we measured activity as well as physiologic parameters in vasectomized male-female pairs: heart rate, blood pressure, and body temperature. Seven singly housed males that were previously implanted with telemetry were vasectomized and paired with females. Data were collected before and after pairing at specific timepoints in the first study. A second study employed four nonvasectomized, singly housed males to determine if the physiologic effects observed in the first study could be due simply to the increased cage size due to pairing. Results indicated that pair-housing with a female resulted immediately in a significant increase in blood pressure, body temperature, and heart rate. Over the course of a week of being paired, the males showed a significant decline in blood pressure; body temperature remained elevated, though at a lower level than during the immediate response. The second study suggested that increased cage size alone could not account for the immediate results in Experiment 1, inasmuch as no effects were found on our measures. Although the sample sizes for the studies were small, we discuss how our results are similar to, and differ from, previous studies, as well as the clinical significance and welfare implications. This information may be useful in designing long-term studies using sexually mature males while providing stable social support to animals.
期刊介绍:
The objective of the American Journal of Primatology is to provide a forum for the exchange of ideas and findings among primatologists and to convey our increasing understanding of this order of animals to specialists and interested readers alike.
Primatology is an unusual science in that its practitioners work in a wide variety of departments and institutions, live in countries throughout the world, and carry out a vast range of research procedures. Whether we are anthropologists, psychologists, biologists, or medical researchers, whether we live in Japan, Kenya, Brazil, or the United States, whether we conduct naturalistic observations in the field or experiments in the lab, we are united in our goal of better understanding primates. Our studies of nonhuman primates are of interest to scientists in many other disciplines ranging from entomology to sociology.