Physiologic Consequences of Housing Adult Male Cynomolgus Monkeys (Macaca fascicularis) in Heterosexual Pairs: A Pilot Study Using Implanted Biotelemetry

IF 2 3区 生物学 Q1 ZOOLOGY
Rosemary Santos, Dong-Binh Tran, Dingzhou Li, Peter Harris, Jan Bernal, Steven Kreuser, Erin Ricciardi, Siri Skowronek, Kiran Palyada, John P. Capitanio
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Abstract

Facilities may forgo attempting to socially house adult males due to fear of animal injury, study disruptions, and confounding data results. To leverage the potential advantages of male–female pairs, and to understand the impact on measures typically used in safety pharmacology studies, we measured activity as well as physiologic parameters in vasectomized male-female pairs: heart rate, blood pressure, and body temperature. Seven singly housed males that were previously implanted with telemetry were vasectomized and paired with females. Data were collected before and after pairing at specific timepoints in the first study. A second study employed four nonvasectomized, singly housed males to determine if the physiologic effects observed in the first study could be due simply to the increased cage size due to pairing. Results indicated that pair-housing with a female resulted immediately in a significant increase in blood pressure, body temperature, and heart rate. Over the course of a week of being paired, the males showed a significant decline in blood pressure; body temperature remained elevated, though at a lower level than during the immediate response. The second study suggested that increased cage size alone could not account for the immediate results in Experiment 1, inasmuch as no effects were found on our measures. Although the sample sizes for the studies were small, we discuss how our results are similar to, and differ from, previous studies, as well as the clinical significance and welfare implications. This information may be useful in designing long-term studies using sexually mature males while providing stable social support to animals.

成年雄性食蟹猴(Macaca fascularis)在异性伴侣中居住的生理后果:一项使用植入式生物遥测技术的初步研究
由于担心动物受伤、研究中断和混淆数据结果,设施可能会放弃尝试社会性地收容成年雄性。为了充分利用男女配对的潜在优势,并了解对安全药理学研究中通常使用的测量方法的影响,我们测量了输精管结扎的男女配对的活动和生理参数:心率、血压和体温。7只先前植入遥测装置的独居雄鼠被切除输精管并与雌鼠配对。在第一项研究中,在配对前后的特定时间点收集数据。第二项研究采用了四只未结扎的单笼雄鼠,以确定在第一项研究中观察到的生理效应是否仅仅是由于配对导致的笼尺寸增加。结果表明,与雌鼠成对居住会立即导致血压、体温和心率显著升高。在一周的配对过程中,雄鼠的血压显著下降;体温仍在升高,但低于立即反应时的水平。第二项研究表明,仅仅增加笼子尺寸并不能解释实验1中的直接结果,因为我们的措施没有发现任何影响。虽然这些研究的样本量很小,但我们讨论了我们的结果与以往研究的相似之处和不同之处,以及临床意义和福利意义。这一信息可能有助于设计使用性成熟雄性的长期研究,同时为动物提供稳定的社会支持。
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来源期刊
CiteScore
4.50
自引率
8.30%
发文量
103
审稿时长
4-8 weeks
期刊介绍: The objective of the American Journal of Primatology is to provide a forum for the exchange of ideas and findings among primatologists and to convey our increasing understanding of this order of animals to specialists and interested readers alike. Primatology is an unusual science in that its practitioners work in a wide variety of departments and institutions, live in countries throughout the world, and carry out a vast range of research procedures. Whether we are anthropologists, psychologists, biologists, or medical researchers, whether we live in Japan, Kenya, Brazil, or the United States, whether we conduct naturalistic observations in the field or experiments in the lab, we are united in our goal of better understanding primates. Our studies of nonhuman primates are of interest to scientists in many other disciplines ranging from entomology to sociology.
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