Association between telomere length and atopic dermatitis among school-age children

IF 4.6 2区医学 Q2 ALLERGY

Clinical and Translational Allergy Pub Date : 2025-05-28 DOI:10.1002/clt2.70066

Hsin-Yi Huang, Kun-Hua Sheen, Chi-Yen Hung, Ju Chang-Chien, Shih-Ling Wang, Chia-Hua Ho, Hui-Ju Tsai, Tsung-Chieh Yao

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Abstract

Background

Atopic dermatitis is a common chronic skin disease in children. Whether telomere length is associated with atopic dermatitis remains unclear. This population-based case-control study aimed to investigate the association between telomere length and atopic dermatitis in school-age children.

Methods

In this cross-sectional analysis, we included 1084 singleton term-born children (608 males; mean age 6.4 years) from the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren cohort. Telomere length was measured using quantitative real-time polymerase chain reaction, log-transformed and was analyzed in quartiles. The main outcome was atopic dermatitis defined as having physician-diagnosed atopic dermatitis and the presence of atopic dermatitis in the last 12 months. Regression analyses were used to assess the relationship between telomere length and atopic dermatitis.

Results

Telomere length was significantly inversely associated with childhood atopic dermatitis after adjusting for child's age, sex, overweight or obesity, birth season, childhood allergic diseases, environmental tobacco smoke, parental history of allergic diseases, parental educational level, and breastfeeding status (p__trend = 0.01). Specifically, when telomere length was classified into quartiles, children in the shortest (fourth) telomere length quartile had a 1.88-fold higher probability of atopic dermatitis compared to those in the longest (first) quartile (95% confidence interval: 1.13–3.14). Stratified analyses showed that the associations were stronger in males and non-breastfed children, with no significant associations observed in females or breastfed children.

Conclusion

This study provides new evidence suggesting an association between shorter telomere length and atopic dermatitis in school-age children.

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端粒长度与学龄儿童特应性皮炎的关系

背景特应性皮炎是儿童常见的慢性皮肤病。端粒长度是否与特应性皮炎有关尚不清楚。这项基于人群的病例对照研究旨在调查端粒长度与学龄儿童特应性皮炎之间的关系。方法在横断面分析中，我们纳入了1084例单胎足月新生儿(608例男性；平均年龄6.4岁)，来自台湾学童群体全球健康纵向调查。端粒长度采用实时定量聚合酶链反应测定，对数转化并以四分位数进行分析。主要结果是特应性皮炎，定义为医生诊断的特应性皮炎和过去12个月内特应性皮炎的存在。回归分析用于评估端粒长度与特应性皮炎之间的关系。结果在调整儿童年龄、性别、超重或肥胖、出生季节、儿童过敏性疾病、环境吸烟、父母过敏性疾病史、父母文化程度、母乳喂养状况后，端粒长度与儿童特应性皮炎呈显著负相关（p_trend = 0.01）。具体来说，当端粒长度被划分为四分位数时，最短（第四个）端粒长度四分位数的儿童患特应性皮炎的概率是最长（第一个）四分位数的儿童的1.88倍（95%置信区间：1.13-3.14）。分层分析显示，这种关联在男性和非母乳喂养的儿童中更强，而在女性和母乳喂养的儿童中没有观察到显著的关联。结论本研究为学龄期儿童端粒长度较短与特应性皮炎之间的关系提供了新的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Allergy Immunology and Microbiology-Immunology

CiteScore

7.50

自引率

4.50%

发文量

117

审稿时长

12 weeks

期刊介绍： Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.