Investigation of the Effects of Solvents and Temperature on the Aggregation, Binding, and Phase Partitioning Nature of Triton X-100 with Promazine Hydrochloride

IF 1.9 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2025-05-29 DOI:10.1002/slct.202501054

Ashraful Alam, Md. Abu Taleb, Md. Masum Reza, Shamim Mahbub, Javed Masood Khan, Muhammad Wajid Ullah, Shahed Rana, Md. Anamul Hoque

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引用次数: 0

Abstract

Herein, the aggregation, binding, and phase partitioning nature of triton X-100 (TX-100) with promazine hydrochloride (PMZ) have been examined applying spectroscopic and cloud point measurement methods. The PMZ mediated aggregation of TX-100 was found to be disfavored with the elevation of temperature. The binding constant (K_b) of the complexation of TX-100 with PMZ was evaluated applying Benesi–Hildebrand (BH) plot, where the K_b values showed the dependency on solvent composition and experimental temperature. Cloud point (CP) of TX-100 + PMZ mixture was noticed to be reliant on both concentration and solvent variation. The micellization and complexation of the TX-100 + PMZ system in all the investigated solvents were obtained as spontaneous with negative free energy changes values, whereas clouding phenomenon was nonspontaneous (). For the TX-100 + PMZ system, the enthalpy changes ( and entropy changes values indicated the presence of hydrophobic interaction, dipole–dipole forces and π–π interactions. The compensation parameters (intrinsic enthalpy gain () and compensation temperature (T_c)) were also calculated and explained logically.

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溶剂和温度对Triton X-100与盐酸丙嗪的聚集、结合和相分配性质的影响

本文采用光谱学和云点测量方法研究了triton X-100 （TX-100）与盐酸丙嗪（PMZ）的聚集、结合和相分配性质。PMZ介导的TX-100的聚集随着温度的升高而减弱。采用Benesi-Hildebrand （BH）图计算了TX-100与PMZ络合的结合常数Kb， Kb值与溶剂组成和实验温度有关。TX-100 + PMZ混合物的浊点（CP）随浓度和溶剂的变化而变化。TX-100 + PMZ体系在所有溶剂中的胶束和络合都是自发的，自由能变化值为负，而云化现象是非自发的（）。对于TX-100 + PMZ体系，焓变和熵变值表明存在疏水相互作用、偶极-偶极力和π -π相互作用。对补偿参数（固有焓增益）和补偿温度（Tc）进行了计算和逻辑解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.