Feasibility of lifestyle interventions for cognition in adults with low education

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-05-29 DOI:10.1002/alz.70232

Daniel O. Clark, Huiping Xu, Christy C. Tangney, Annie W. Lin, Shannon L. Risacher, Andrew J. Saykin, Robert V. Considine, Holly J. Garringer, Lyndsi Moser, Amy Carter, Catherine M. Miller, Briana Sprague, Christopher M. Callahan, Frederick W. Unverzagt

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引用次数: 0

Abstract

INTRODUCTION

We report the feasibility and cognitive outcomes of a stage 1b randomized trial testing 3 months of home-delivered high polyphenol snacks (e.g., nuts, berries) and online speed of processing training among older adults with 12 or fewer years of education.

METHODS

One hundred eighty participants were randomized to polyphenol-rich snacks and online cognitive training, polyphenol snacks and online control games, control snacks and cognitive training, or control snacks and control games. The outcomes were feasibility of recruitment, retention, and adherence (RRA) and change in a cognitive composite score.

RESULTS

Feasibility goals for RRA were met. Improvements in the cognitive score were evident in all groups (effect sizes ranged from 0.15–0.35) but improvements did not differ significantly between arms.

DISCUSSION

Dementia prevention trials with longer intervention and follow-up focused on adults with limited formal education should be considered given the observed cognitive gains in those with elevated risk.

Clinical Trial Registration: ClinicalTrials.gov (NCT03419052).

Highlights

The study focused on adults with low education; a group with a high risk for cognitive decline.
Two interventions were tested in a randomized trial design that included two controls.
Nutrition intervention was designed with input from adults with limited education.
Primary outcome: A cognitive composite score was formed from five established cognitive tests.
The study establishes the feasibility of dementia prevention targeting adults with low education.

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生活方式干预对低教育成人认知的可行性

我们报告了一项1b期随机试验的可行性和认知结果，该试验对受教育12年或以下的老年人进行了为期3个月的家庭提供的高多酚零食（如坚果、浆果）和在线处理训练的速度进行了测试。方法将180名参与者随机分为富含多酚零食和网络认知训练组、多酚零食和网络控制游戏组、控制零食和认知训练组、控制零食和控制游戏组。结果是招募、保留和坚持（RRA）的可行性和认知综合评分的变化。结果满足RRA的可行性指标。认知评分的改善在所有组中都很明显（效应值从0.15-0.35不等），但两组之间的改善没有显著差异。鉴于观察到高风险人群认知能力的提高，应考虑针对受正规教育程度有限的成年人进行更长时间干预和随访的痴呆预防试验。临床试验注册：ClinicalTrials.gov （NCT03419052）。该研究主要针对受教育程度较低的成年人；认知能力下降的高危人群。在包括两个对照的随机试验设计中测试了两种干预措施。营养干预是根据受教育程度有限的成年人的意见设计的。主要结果：认知综合评分由五项已建立的认知测试形成。该研究确立了针对低教育程度成人预防痴呆的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.