Preparation of highly charged zwitterionic nanochitin for stabilizing Pickering emulsions

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2025-05-27 DOI:10.1016/j.carbpol.2025.123818

Qiannuo Li , Lei Zhang , Xue Gao , Zhongshuai Gao , Mei Cui , Renliang Huang , Rongxin Su

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Abstract

Zwitterionically charged nanochitin has broad applications in diverse environments. The current process mainly involves partial deacetylation, which is followed by carboxylation via TEMPO-mediated oxidation. Herein, we develop an eco-friendly strategy that integrates phosphorylation with partial deacetylation to prepare highly charged zwitterionic nanochitin (P-De-NCh). The chitin fibers were soaked in an aqueous solution containing NH₄H₂PO₄ and urea, followed by heat curing at 150 °C for 30 min, the phosphorylated chitin with a degree of substitution of 0.19 was obtained, and the yield of phosphorylated nanochitin (P-NCh) was 80.2 %. After deacetylation in NaOH solution and mechanical fibrillation, the resulting zwitterionic nanochitin contained both anionic (-PO₃²⁻) and cationic (-NH₃⁺) groups with a degree of phosphorylation of 0.14 and a degree of deacetylation of 0.26, and displayed a high crystallinity of 77.5 %. Additionally, the prepared P-De-NCh demonstrated high antibacterial activity, thermal stability, and colloidal stability over a wide pH range. Furthermore, the potential of this sustainable P-De-NCh as an emulsifier for preparing Pickering emulsions with good stability in both acidic and alkaline environments was presented. Therefore, this simple and eco-friendly process is expected to hold significant potential in the large-scale production of zwitterionic nanochitin.

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稳定皮克林乳状液的高电荷两性离子纳米几丁质的制备

带两性离子的纳米甲壳素在不同的环境中有着广泛的应用。目前的过程主要包括部分去乙酰化，然后通过tempo介导的氧化进行羧化。在此，我们开发了一种生态友好的策略，将磷酸化与部分去乙酰化相结合，以制备高电荷的两性离子纳米几丁质（P-De-NCh）。将甲壳素纤维浸泡在含有NH4H2PO4和尿素的水溶液中，在150℃下加热固化30 min，得到取代度为0.19的磷酸化甲壳素，磷酸化纳米甲壳素（P-NCh）的收率为80.2%。在NaOH溶液中脱乙酰和机械颤振后，得到的两性离子纳米几丁质同时含有阴离子（-PO32−）和阳离子（-NH3+）基团，磷酸化度为0.14，脱乙酰度为0.26，结晶度为77.5%。此外，制备的P-De-NCh在较宽的pH范围内表现出较高的抗菌活性、热稳定性和胶体稳定性。此外，这种可持续的P-De-NCh作为乳化剂的潜力，在酸性和碱性环境中都具有良好的稳定性。因此，这种简单、环保的工艺有望在两性离子纳米甲壳素的大规模生产中具有重要的潜力。

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.