Aerobic exercise alleviates chronic allergic airway inflammation by regulating the circMETTL9/EIF4A3/IGFBP3 axis

IF 4.4 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-05-26 DOI:10.1016/j.cellsig.2025.111889

Haixia Wang , Yuanmin Jia , Bin Ma , Ting Gao , Hui Wei , Danyang Li , Junlian Gu , Ou Chen , Shouwei Yue

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引用次数: 0

Abstract

Aerobic exercise has been recommended as a non-pharmacological treatment for asthma. Previous studies have shown that circMETTL9 regulates cellular inflammation, apoptosis, and oxidative stress levels. However, whether aerobic exercise can modulate the expression of circMETTL9 to alleviate chronic allergic airway inflammation remains unclear. In this study, we established a mouse model of chronic allergic lung inflammation with aerobic exercise intervention to assess its effects. Our results demonstrate that aerobic exercise exerts anti-inflammatory, anti-proliferative, anti-apoptotic, and anti-oxidative stress effects by regulating the circMETTL9/EIF4A3/IGFBP3 axis. Mechanistically, we found that circMETTL9 binding to EIF4A3 does not affect EIF4A3 expression. However, EIF4A3 positively regulates both the protein and mRNA levels of IGFBP3. Specifically, circMETTL9 binds to EIF4A3 to inhibit IGFBP3 transcription and translation. This study identifies a novel potential target and research direction for treating chronic allergic lung inflammation.

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有氧运动通过调节circmetl9 /EIF4A3/IGFBP3轴减轻慢性变应性气道炎症

有氧运动已被推荐作为一种非药物治疗哮喘的方法。先前的研究表明circMETTL9调节细胞炎症、凋亡和氧化应激水平。然而，有氧运动是否可以调节circmetl9的表达，从而减轻慢性变应性气道炎症尚不清楚。在这项研究中，我们建立了慢性变应性肺部炎症小鼠模型，并进行了有氧运动干预，以评估其效果。我们的研究结果表明，有氧运动通过调节circMETTL9/EIF4A3/IGFBP3轴发挥抗炎、抗增殖、抗凋亡和抗氧化应激作用。机制上，我们发现circMETTL9结合EIF4A3并不影响EIF4A3的表达。然而，EIF4A3正向调节IGFBP3的蛋白和mRNA水平。具体来说，circMETTL9结合EIF4A3抑制IGFBP3的转录和翻译。本研究为慢性变应性肺部炎症的治疗提供了新的潜在靶点和研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.