Culturally targeted messaging and racial equity in SARS-CoV-2 antibody testing by multiplex salivary measurement: Protocol overview of a SeroNet investigation

IF 3.5 Q2 IMMUNOLOGY
Todd Lucas , Christopher D. Heaney , Steve W. Granger , Kent D. Key , Maria Knight Lapinski , Nicole Jones , Nigel Paneth , Ahnalee M. Brincks , Anurag Dawadi , Leah Maschino , Lindsey Rose , Monicia Summers , Rachel Weisbrod , Nora Pisanic , Olivia Aspiras , Stefan M.M. Goetz , Douglas A. Granger
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引用次数: 0

Abstract

Better understanding racial disparities observed during the COVID-19 pandemic can be aided by SARS-CoV-2 serology testing. However, racial minorities may be underrepresented in serosurveillance efforts not only due to lack of testing accessibility, but also due to hesitancy towards participating in antibody testing programs stemming from medical mistrust. We designed a randomized control trial to evaluate how non-invasive salivary antibody testing and culturally targeted communication might be used to promote racial equity in uptake of SARS-CoV-2 serology testing during the COVID-19 pandemic. To evaluate these approaches, we recruited African American and White American participants from Flint, Michigan. Participants viewed a novel, animated didactic video about SARS-CoV-2 antibody testing, with half of African Americans viewing a culturally targeted version. We measured cognitive and affective responses that indicated receptivity to SARS-CoV-2 serology testing. We also provided a non-invasive salivary antibody screening opportunity, and we measured screening uptake as a behavioral outcome. Finally, we measured baseline sociodemographic, psychological, and health factors that could affect these responses. In addition to evaluating health communication approaches, multiplex SARS-CoV-2 antibody profiles can be subsequently linked to prescreen measures, and to inflammatory markers that were concomitantly measured in whole saliva. Ultimately, we aim to reduce COVID-19 racial disparities and bolster future pandemic preparedness through promoting equity in understanding and uptake of serology testing.
多重唾液测量在SARS-CoV-2抗体检测中的文化目标信息和种族平等:SeroNet调查的协议概述
SARS-CoV-2血清学检测有助于更好地了解COVID-19大流行期间观察到的种族差异。然而,少数族裔在服务监测工作中的代表性可能不足,这不仅是因为缺乏检测的可及性,还因为由于医学不信任而对参与抗体检测项目犹豫不决。我们设计了一项随机对照试验,以评估在COVID-19大流行期间,如何利用无创唾液抗体检测和文化定向交流来促进接受SARS-CoV-2血清学检测的种族平等。为了评估这些方法,我们从密歇根州弗林特市招募了非裔美国人和美国白人参与者。参与者观看了一段关于SARS-CoV-2抗体检测的新颖动画教学视频,一半的非裔美国人观看了有文化针对性的版本。我们测量了表明对SARS-CoV-2血清学检测具有接受性的认知和情感反应。我们还提供了一个非侵入性唾液抗体筛查的机会,我们测量了作为行为结果的筛查摄取。最后,我们测量了可能影响这些反应的基线社会人口、心理和健康因素。除了评估健康沟通方法外,多种SARS-CoV-2抗体谱还可以随后与预筛查措施联系起来,并与在全唾液中同时测量的炎症标志物联系起来。最终,我们的目标是通过促进对血清学检测的公平理解和接受,减少COVID-19的种族差异,并加强未来的大流行防范。
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来源期刊
Brain, behavior, & immunity - health
Brain, behavior, & immunity - health Biological Psychiatry, Behavioral Neuroscience
CiteScore
8.50
自引率
0.00%
发文量
0
审稿时长
97 days
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