Seroprevalence of varicella zoster virus in Colombia: A community-based mixture models study

IF 1.5 Q4 INFECTIOUS DISEASES

IJID regions Pub Date : 2025-05-07 DOI:10.1016/j.ijregi.2025.100662

Viviana Lenis-Ballesteros , Doracelly Hincapié-Palacio , Jesús Ochoa , Marta Ospina , Seti Buitrago

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Abstract

Objectives

To describe the distribution of immunoglobulin (Ig) G antibodies against varicella by sociodemographic characteristics during the period before vaccination in Medellín, Antioquia, Colombia.

Methods

A population seroprevalence based on a previous study carried out in men and women aged 6-64 years, residing in the urban and rural zone of Medellín, Antioquia, Colombia in 2009. A probability sample of 2124 individuals was selected using a multistage sampling design. IgG antibodies against varicella zoster virus were determined in human serum/plasma by an enzyme-linked immunosorbent assay test. Global seroprevalence levels were calculated, considering a sample expansion factor, allowing inference to the population. Antibody distribution was explored worldwide by sex and zone of residence, using finite mixture models.

Results

Global seropositivity was 85.9% (95% confidence interval [CI]: 82.9-88.5) using the manufacturer’s cutoff and 81.5% (95% CI: 78.0-88.5) using the complete data from antibody distribution. Significant seronegativity was detected in the group from 6 to 17 years of age of 20.6% (95% CI: 14.8-27.9), without differences by sex and zone of residence.

Conclusions

The seronegativity in the 6-17 age group shows the need to periodically monitor antibody prevalence in children and young people to guide new vaccination and transmission prevention strategies.

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哥伦比亚水痘带状疱疹病毒血清流行率：基于社区的混合模型研究

目的了解哥伦比亚安蒂奥基亚Medellín地区接种水痘疫苗前免疫球蛋白（Ig） G抗体的社会人口学特征。方法对2009年居住在哥伦比亚安蒂奥基亚Medellín城市和农村地区6-64岁男性和女性进行人群血清流行病学调查。采用多阶段抽样设计，选取了2124人的概率样本。采用酶联免疫吸附试验测定人血清/血浆中水痘带状疱疹病毒IgG抗体。考虑到样本扩展因子，计算了全球血清阳性率水平，从而对人群进行了推断。使用有限混合模型，按性别和居住区域探索抗体在全球范围内的分布。结果使用制造商截止值，全球血清阳性为85.9%(95%置信区间[CI]: 82.9-88.5)；使用抗体分布完整数据，全球血清阳性为81.5% （95% CI: 78.0-88.5）。6 - 17岁组血清明显阴性20.6% (95% CI: 14.8-27.9)，无性别和居住地区差异。结论6-17岁人群血清抗体呈阴性，说明需要定期监测儿童和青少年的抗体流行情况，以指导新的疫苗接种和预防传播策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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