{"title":"A cross-sectional, observational study on quality of life in epilepsy patients","authors":"Devulapalli Shilpasree , Muthyala Sathish , Ruhul Amin Ahmed , Thirunagiri Praveen Kumar","doi":"10.1016/j.dscb.2025.100241","DOIUrl":null,"url":null,"abstract":"<div><div>The study involved a cross-sectional, observational patient survey using QOLIE-31 to assess relationships between demographic characteristics (age, gender, and residence status) and clinical factors (seizure type, epilepsy duration, comorbid conditions, risk factors, therapy options (monotherapy or polytherapy) on health-related quality of life (QOL) in people with epilepsy. Research data collection includes 260 epilepsy patients who have visited Neurology departments of Khammam region tertiary care hospitals. The QOLIE-31 survey revealed unsatisfactory mean scores in the Seizure Worry (46.05 ± 7.59) and Overall Quality of Life (44.21 ± 8.14) domains and Social Functioning (43.31 ± 9.69) dimensions. All variables along with seizure type and therapy type and disease duration along with gender and age and comorbidities had substantial influence on QOL scores among epilepsy patients. The QOL scores tended to be lower for patients with focal onset aware seizures and received multiple antiseizure medications. In contrast, patients without health conditions who received one anti-seizure medication reported better QOL scores. The statistical results showed that both demographic elements and clinical measurements created significant effects on QOL (ANOVA <em>p</em> < 0.0001). Treating patients with a single drug regimen of levetiracetam resulted in more beneficial treatment outcomes and enhanced quality of life.</div></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"19 ","pages":"Article 100241"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain disorders (Amsterdam, Netherlands)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666459325000617","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The study involved a cross-sectional, observational patient survey using QOLIE-31 to assess relationships between demographic characteristics (age, gender, and residence status) and clinical factors (seizure type, epilepsy duration, comorbid conditions, risk factors, therapy options (monotherapy or polytherapy) on health-related quality of life (QOL) in people with epilepsy. Research data collection includes 260 epilepsy patients who have visited Neurology departments of Khammam region tertiary care hospitals. The QOLIE-31 survey revealed unsatisfactory mean scores in the Seizure Worry (46.05 ± 7.59) and Overall Quality of Life (44.21 ± 8.14) domains and Social Functioning (43.31 ± 9.69) dimensions. All variables along with seizure type and therapy type and disease duration along with gender and age and comorbidities had substantial influence on QOL scores among epilepsy patients. The QOL scores tended to be lower for patients with focal onset aware seizures and received multiple antiseizure medications. In contrast, patients without health conditions who received one anti-seizure medication reported better QOL scores. The statistical results showed that both demographic elements and clinical measurements created significant effects on QOL (ANOVA p < 0.0001). Treating patients with a single drug regimen of levetiracetam resulted in more beneficial treatment outcomes and enhanced quality of life.
该研究采用QOLIE-31进行横断面观察性患者调查,以评估人口统计学特征(年龄、性别和居住状况)与临床因素(癫痫发作类型、癫痫持续时间、合并症、危险因素、治疗选择(单一治疗或多种治疗)与癫痫患者健康相关生活质量(QOL)之间的关系。研究数据收集包括260名到Khammam地区三级保健医院神经科就诊的癫痫患者。QOLIE-31调查显示,癫痫发作焦虑(46.05±7.59)、整体生活质量(44.21±8.14)和社会功能(43.31±9.69)三个维度的平均得分不理想。癫痫发作类型、治疗类型、病程、性别、年龄、合并症等因素均对癫痫患者的生活质量评分有显著影响。局灶性意识性癫痫发作并接受多种抗癫痫药物治疗的患者,其生活质量评分往往较低。相比之下,接受一种抗癫痫药物治疗的无健康状况患者的生活质量评分更高。统计结果显示,人口统计学因素和临床测量对生活质量均有显著影响(ANOVA p <;0.0001)。用左乙拉西坦单一药物治疗方案治疗患者可获得更有益的治疗结果并提高生活质量。