Wen-Yu Huang , Hong-Tao Li , Wang-Cui Xu, Ya-Ting Shao, Han-Wei Ruan, Jie Guo, Wei Li
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引用次数: 0
Abstract
In our continuous work on the isolation of endophytes, the fungal strain KMU22201 was obtained from the roots of Delphinium yunnanense. Based on phylogenetic analysis, it was identified as Paracylindrocarpon sp. Despite the potential of this endophytic fungus, to our knowledge, its genetic and metabolic diversity, functional activity, and regulatory interactions with D. yunnanense remain to be explored. Investigation of the secondary metabolites of the endophytic Paracylindrocarpon sp. KMU22201 led to the isolation of one undescribed chromene glucoside, dehydromene (1), along with the reported compounds, 2,2-dimethyl-2H-1-benzopyran-6-ol (2) and methyl-p-hydroquinone (3). The structures were established unambiguously via extensive spectroscopic analysis. According to structural characteristic, a plausible biosynthetic pathway for compounds 1–3 was proposed. Bio-evaluations indicated that compound 1 exhibited weak anti-acetylcholinesterase and anti-inflammatory activities.
期刊介绍:
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.