Long-term survival after multimodal treatment of sinonasal NUT carcinoma: a case report

IF 4 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral oncology Pub Date : 2025-05-28 DOI:10.1016/j.oraloncology.2025.107392

J.A. Rijken , M. de Ridder , L.A. Devriese , G.E. Breimer

引用次数: 0

Abstract

Sinonasal NUT carcinoma is a highly aggressive malignancy with poor prognosis. This case demonstrates that combined surgical resection, high-dose radiotherapy, and chemotherapy can lead to long-term remission, with the patient remaining disease-free after five years. Early diagnosis and a multidisciplinary approach are crucial. Continued research into targeted therapies like BET inhibitors holds promise for improving outcomes in this rare, challenging tumor.

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多模式治疗鼻窦炎后的长期生存：1例报告

鼻窦NUT癌是一种侵袭性强、预后差的恶性肿瘤。该病例表明，联合手术切除、高剂量放疗和化疗可导致长期缓解，患者在5年后仍无疾病。早期诊断和多学科治疗至关重要。对靶向治疗如BET抑制剂的持续研究有望改善这种罕见的、具有挑战性的肿瘤的治疗结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.