Progression of differentiation of iPSCs into specific subtypes of neurons

IF 2.2 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2025-05-01 DOI:10.1016/j.diff.2025.100869

Jingwen Wang , Ruijie Ji , Lei Zhang , Xiang Cheng , Xinhua Zhang

引用次数: 0

Abstract

Induced pluripotent stem cells (iPSCs), generated through somatic cell reprogramming, exhibit self-renewal capacity and multilineage differentiation potential. In recent years, iPSC-derived neurons have emerged as a significant platform for researching mechanisms and developing therapies for neurological diseases. This paper reviews the targeted differentiation strategies of iPSCs into dopaminergic neurons, motor neurons, cholinergic neurons and medium spinal neurons, providing detailed insights into the differentiation processes. Additionally, this paper discusses the challenges associated with the future application of iPSCs-derived neurons in the treatment of nervous system diseases are also discussed in this paper, aiming to provide references for the application of iPSCs in cellular therapies for neurodegenerative disorders.

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多能干细胞向特定神经元亚型分化的进展

诱导多能干细胞（iPSCs）是通过体细胞重编程产生的，具有自我更新能力和多系分化潜力。近年来，ipsc衍生的神经元已成为研究神经系统疾病机制和开发治疗方法的重要平台。本文综述了iPSCs定向分化为多巴胺能神经元、运动神经元、胆碱能神经元和中脊髓神经元的策略，并对其分化过程进行了详细的了解。此外，本文还讨论了iPSCs衍生神经元在神经系统疾病治疗中的未来应用所面临的挑战，旨在为iPSCs在神经退行性疾病的细胞治疗中的应用提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.