Does hypertriglyceridemia induce increased oxidative stress in obese dogs?

IF 2.2 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2025-05-26 DOI:10.1016/j.rvsc.2025.105723

Yuri Lima Pereira , Laura Elisa Raviolo , Gabriela Fernanda Vitoretti Machado , Danielle Venturini , Karina Keller Marques da Costa Flaiban

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引用次数: 0

Abstract

Obesity is considered the most common nutritional disorder in pets. It triggers a low-grade inflammatory process that can lead to increased oxidative stress and contribute to various diseases. The purpose of this study was to evaluate the systemic levels of oxidative stress biomarkers in dogs with overweight, obesity and ideal body condition score (BCS). Fifty-eight adult and senior dogs were selected and divided into three groups: overweight (n = 20), obese (n = 20), and ideal BCS (n = 18). Oxidative stress biomarkers were measured using lipid peroxidation products, by ferrous oxidation-xylenol orange (FOX), advanced oxidative protein products (AOPP), and total reactive antioxidant potential (TRAP), with C-reactive protein (CRP) concentration used as an inflammatory biomarker. Protein oxidation was observed in overweight and obese dogs, as evidenced by elevated AOPP levels (p = 0.004) and their ratio to antioxidant levels (AOPP/TRAP) through the prooxidant-antioxidant index (PAI) (p = 0.015) in obese dogs. In obese dogs with hypertriglyceridemia, lipid oxidation (p = 0.018) was observed in addition to protein oxidation (p < 0.001). Furthermore, a positive correlation was observed between the triglyceride levels and AOPP (r = 0.716, p < 0.001) and PAI (r = 0.749, p < 0.001) concentrations. Finally, we concluded that obesity alone may not be sufficient to induce increased oxidative stress and that hypertriglyceridemia is correlated with protein and lipid oxidation in obese dogs.

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高甘油三酯血症是否会导致肥胖狗的氧化应激增加？

肥胖被认为是宠物最常见的营养失调。它会引发低度炎症过程，导致氧化应激增加，并导致各种疾病。本研究的目的是评估超重、肥胖和理想身体状况评分（BCS）犬的氧化应激生物标志物的全身水平。选择成年和老年犬58只，分为超重组（n = 20）、肥胖组（n = 20）和理想BCS组（n = 18）。氧化应激生物标志物采用脂质过氧化产物、氧化亚铁-二甲醇橙（FOX）、高级氧化蛋白产物（AOPP）和总活性抗氧化电位（TRAP）来测量，c反应蛋白（CRP）浓度作为炎症生物标志物。在超重和肥胖犬中观察到蛋白质氧化，其证据是肥胖犬的AOPP水平升高（p = 0.004），其与抗氧化水平的比值（AOPP/TRAP）通过促氧化-抗氧化指数（PAI）（p = 0.015）得到提高。在高甘油三酯血症的肥胖狗中，除了蛋白质氧化外，还观察到脂质氧化（p = 0.018） (p <；0.001)。此外，甘油三酯水平与AOPP呈正相关(r = 0.716, p <；0.001)和PAI (r = 0.749, p <；0.001)浓度。最后，我们得出结论，肥胖本身可能不足以诱导氧化应激增加，高甘油三酯血症与肥胖狗的蛋白质和脂质氧化有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.