The impact of anxiety and depression on quality of life in a cohort of inflammatory bowel disease patients from Northeastern of Brazil

Gastroenterología y Hepatología (English Edition) Pub Date : 2025-05-29 DOI:10.1016/j.gastre.2025.502283

Raiza Lima Silva , Francisca Isabelle da Silva e Sousa , Gabriel Lucas Ferreira da Silva , Victória Danielly Rabelo Almeida , Simão Barbosa Silva , Mateus Mendes Santos Freire , Marcellus Henrique Loiola Ponte de Souza , Lucia Libanez Bessa Campelo Braga

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Abstract

Objective

This study aims to assess whether the association between chronic pathologies and depressive and/or anxious disorders is high, resulting in a reduction in the patient's quality of life.

Patients and methods

This is a prospective cross-sectional study with a descriptive and analytical design. Sociodemographic data and lifestyle habits were collected. Subsequently, the Inflammatory Bowel Disease Questionnaire (IBDQ) and the Hospital Anxiety and Depression Scale (HADS) were applied.

Results

A total of 141 patients participated in the study, with a mean age of 45.78 (SD 16.01) years, of which 60.3% were female (n = 85) and 39.7% were male (n = 56). 58.9% had ulcerative colitis (UC) (n = 83), and 41.1% had Crohn's disease (CD) (n = 58). 16.5% of patients had a previous diagnosis of generalized anxiety disorder (GAD) and/or major depression (MD) (n = 23). Regarding IBDQ scores, participants with anxiety had significantly lower mean scores in all IBDQ items (p < 0.001), while the depression diagnosis obtained significantly lower mean values for systemic (p = 0.015), emotional (p = 0.001), and intestinal symptoms (p = 0.005).

Conclusion

The results indicate that anxiety and depression negatively impact the quality of life of patients with IBD independently of the disease activity.

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焦虑和抑郁对巴西东北部炎症性肠病患者生活质量的影响

目的本研究旨在评估慢性病理与抑郁和/或焦虑障碍之间的相关性是否很高，从而导致患者生活质量的降低。患者和方法这是一项具有描述性和分析性设计的前瞻性横断面研究。收集社会人口统计数据和生活习惯。随后采用炎症性肠病问卷（IBDQ）和医院焦虑抑郁量表（HADS）。结果141例患者参与研究，平均年龄45.78 （SD 16.01）岁，其中女性占60.3% (n = 85)，男性占39.7% （n = 56）。58.9%的患者有溃疡性结肠炎（UC）（n = 83）， 41.1%的患者有克罗恩病（CD）（n = 58）。16.5%的患者既往诊断为广泛性焦虑症（GAD）和/或重度抑郁症（MD）（n = 23）。在IBDQ得分方面，焦虑的参与者在所有IBDQ项目上的平均得分显著降低(p <；0.001)，而抑郁诊断在系统（p = 0.015）、情绪（p = 0.001）和肠道症状（p = 0.005）方面的平均值明显较低。结论焦虑和抑郁对IBD患者生活质量的负面影响与疾病活动无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gastroenterología y Hepatología (English Edition)

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