The Noninvasive Measurement of Ocular Rigidity and the Pulsatile Choroidal Volume Change in Children and Young Adults

IF 3.2 Q1 OPHTHALMOLOGY

Ophthalmology science Pub Date : 2025-04-26 DOI:10.1016/j.xops.2025.100814

Martin Reyes , Sage Smith , Kelly Lam, Yasaman Adel, Nimesh B. Patel OD, PhD, Diane N. Sayah OD, PhD

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引用次数: 0

Abstract

Purpose

Measuring ocular rigidity (OR) and the pulsatile choroidal volume change (ΔV) from childhood to adulthood would provide essential insight into the role of the sclera and choroid in axial myopia. A validated measurement method based on Beaton et al (2015) is the only noninvasive, direct, and reliable method available, yet it has never been used in children. This study aims to assess the feasibility and repeatability of noninvasive OR and ΔV measurements in children and young adults using this method.

Design

This is a cross-sectional study.

Subjects

Children and young adults aged 6 to 26 years.

Methods

OCT videos were acquired using enhanced depth imaging mode. A neural network (NN) approach was used to extract the choroid segmentation from OCT videos, which was then used to measure choroidal filling as described by Beaton et al. Ocular rigidity was computed from the ΔV and the ocular pulse amplitude using Friedenwald equation. Intrasession repeatability was assessed for subjects with 2 consecutive measurements of OR.

Main Outcome Measures

Ocular rigidity, pulsatile choroidal volume change, and the method's yield.

Results

Sixty-seven subjects (67 eyes, 27 males) aged 13 ± 6 years were enrolled, and 62 subjects completed the study. ΔV and OR were computed. Out of the 62 videos, 98% (61) of the OCT videos were successfully segmented using the NN approach, with heart rate detectable in 79% (48) of the videos. Average OR and ΔV were 0.027 ± 0.022 μL⁻¹ and 5.7 ± 2.8 μL, respectively (n = 48). The mean submacular choroidal thickness (CT) and pulsatile CT change were 283.6 ± 40.4 μm and 8.36 ± 4.4 μm, respectively. Intrasession repeatability for OR and ΔV was assessed in 31 eyes and was determined to be excellent based on a single measure intraclass correlation coefficient of 0.912, 95% confidence interval (CI) (0.825, 0.956) and 0.941, 95% CI (0.879, 0.972), respectively and a within-subject standard deviation of 0.0037 μL⁻¹ and 1.14 μL, respectively.

Conclusions

Measures of OR and ΔV are achievable in children and young adults and have good repeatability. This noninvasive method can be used to establish structural biomechanical changes of the sclera and choroid with myopic axial elongation in childhood and beyond.

Financial Disclosure(s)

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

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无创测量儿童和青少年眼强直和脉络膜脉动体积变化

目的测量儿童期至成年期眼强直（OR）和脉络膜体积脉动变化（ΔV），为了解巩膜和脉络膜在轴性近视中的作用提供重要依据。基于Beaton等人（2015）的一种经过验证的测量方法是唯一可用的无创、直接和可靠的方法，但从未在儿童中使用。本研究旨在评估使用该方法对儿童和青少年进行无创OR和ΔV测量的可行性和可重复性。这是一项横断面研究。研究对象：6至26岁的儿童和年轻人。方法采用增强深度成像模式采集soct视频。使用神经网络（NN）方法从OCT视频中提取脉络膜分割，然后将其用于测量脉络膜填充，如Beaton等人所述。利用Friedenwald方程从ΔV和眼脉冲幅值计算眼刚度。对连续两次测量OR的受试者进行随访内重复性评估。主要结果测量：眼球刚性，脉络膜脉动体积变化，以及该方法的产出率。结果纳入受试者67例（67只眼，男性27例），年龄13±6岁，完成研究的受试者62例。计算ΔV和OR。在62个视频中，98%（61个）的OCT视频使用神经网络方法成功分割，79%（48个）的视频可检测到心率。平均OR和ΔV分别为0.027±0.022 μL−1和5.7±2.8 μL （n = 48）。平均黄斑下脉络膜厚度（CT）为283.6±40.4 μm，脉搏变化为8.36±4.4 μm。在31只眼睛中评估OR和ΔV的组内重复性，单测量组内相关系数分别为0.912,95%可信区间（CI）（0.825, 0.956）和0.941,95% CI(0.879, 0.972)，组内标准差分别为0.0037 μL−1和1.14 μL，确定为优秀。结论OR和ΔV测量方法在儿童和青壮年均可实现，且具有良好的重复性。这种无创方法可用于确定儿童期及以后近视轴向延伸巩膜和脉络膜的结构生物力学变化。财务披露作者在本文中讨论的任何材料中没有专有或商业利益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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