{"title":"Microbial electrosynthesis meets synthetic biology: Bioproduction from waste feedstocks","authors":"Dijin Zhang , Jee Loon Foo , Matthew Wook Chang","doi":"10.1016/j.biotno.2025.05.001","DOIUrl":null,"url":null,"abstract":"<div><div>Integrating electrochemistry and biology, microbial electrosynthesis (MES) enhances feedstock-to-product conversion by utilizing electroactive microorganisms to harness electrical energy for driving metabolic pathways. Advances in synthetic biology have improved microbial extracellular electron transfer and increased metabolic pathway efficiency, enabling optimized redox balance, expanded substrate versatility and enhanced bioproduction. Given the growing interest in sustainable chemical production and decarbonization, this mini-review highlights recent progress in MES enabled by synthetic biology, with a focus on engineering efficient microbial cell factories for electricity-mediated bioproduction through waste-derived feedstock utilization and carbon capture. We also highlight key challenges limiting MES scalability and propose future directions to enable industrial-scale deployment, unlocking its potential for sustainable, carbon-neutral production and driving transformative advances in biotechnology.</div></div>","PeriodicalId":100186,"journal":{"name":"Biotechnology Notes","volume":"6 ","pages":"Pages 157-163"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biotechnology Notes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2665906925000108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Integrating electrochemistry and biology, microbial electrosynthesis (MES) enhances feedstock-to-product conversion by utilizing electroactive microorganisms to harness electrical energy for driving metabolic pathways. Advances in synthetic biology have improved microbial extracellular electron transfer and increased metabolic pathway efficiency, enabling optimized redox balance, expanded substrate versatility and enhanced bioproduction. Given the growing interest in sustainable chemical production and decarbonization, this mini-review highlights recent progress in MES enabled by synthetic biology, with a focus on engineering efficient microbial cell factories for electricity-mediated bioproduction through waste-derived feedstock utilization and carbon capture. We also highlight key challenges limiting MES scalability and propose future directions to enable industrial-scale deployment, unlocking its potential for sustainable, carbon-neutral production and driving transformative advances in biotechnology.
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