Genomic Deletion of PfHRP2 and PfHRP3 Antigens in Plasmodium falciparum Strains, Ethiopia, 2009

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-05-28 DOI:10.3201/eid3107.241676

Tamirat Gebru Woldearegai, Tina Krüger, Sindew Mekasha Feleke, Hassen Mamo, Tesfaye Gelanew, Vanessa Krohmer, Sabine Belard, Peter G. Kremsner, Jana Held, Miriam Rodi, Andrea Kreidenweiss

引用次数: 0

Abstract

Plasmodium falciparum strains lacking P. falciparum histidine-rich protein 2 (PfHRP2) and PfHRP3 threaten malaria rapid test reliability. We show that pfhrp2/pfhrp3–deleted parasites circulated in Ethiopia as early as 2009, before widespread PfHRP2-based rapid test use, and had high pfhrp3 deletion prevalence. Monitoring of pfhrp2 and of pfhrp3 deletions is needed.

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恶性疟原虫PfHRP2和PfHRP3抗原的基因组缺失，埃塞俄比亚，2009

缺乏富组氨酸蛋白2 （PfHRP2）和PfHRP3的恶性疟原虫威胁疟疾快速检测的可靠性。我们发现，早在2009年，在广泛使用基于pfhrp2的快速检测之前，pfhrp2/pfhrp3缺失的寄生虫就在埃塞俄比亚流行，并且具有很高的pfhrp3缺失率。需要监测pfhrp2和pfhrp3的缺失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.