Transcription factor condensates: Preventing aggregation by DNA binding

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2025-05-29 DOI:10.1016/j.cell.2025.04.034

Alexandre P. Magalhaes, Denes Hnisz

引用次数: 0

Abstract

Transcription factors can form nuclear condensates at genomic sites, and condensates are thought to enhance transcriptional activity. In this issue of Cell, Saad et al. suggest that DNA binding prevents rather than facilitates condensate formation of particularly aggregation-prone transcription factors.

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转录因子凝聚物：通过DNA结合防止聚集

转录因子可以在基因组位点形成核凝析物，凝析物被认为可以增强转录活性。在这一期的Cell中，Saad等人认为DNA结合阻止而不是促进特别容易聚集的转录因子的凝聚形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.