Hydrothermal synthesis of spinel nickel manganate nanoparticles modified glassy carbon electrode: A potential tool for low level detection of fenamate drug

Abstract

The study aims to create a fast and powerful catalyst for the electrochemical detection of the non-steroidal drug mefenamic acid (MA) for quality control and clinical evaluation. The simple hydrothermal process was used to make NiMn₂O₄, which was then changed with a glassy carbon electrode and used for MA electrochemical sensing. For electrochemical reactions, the NiMn₂O₄ electrode offers efficient electron transport channels, accessible active sites, and efficient ion-transport pathways. Various spectroscopic and voltammetric techniques characterized the synthesized materials. We further analyzed the sensitivity and selectivity of the electrode using the DPV method. The NiMn₂O₄/GCE towards MA exhibits good selectivity, better stability, a low LOD (0.91 nM), a broad linear range (0.002–74.18 µM), and a good recovery percentage ± 98.26–99.24. The results of these tests with NiMn₂O₄ toward MA show that it could be used to find biological samples like urine and blood serum. Further, as a fabricated electrode, it is a potential candidate for future electrochemical sensing applications.