Epigenetic mechanisms involved in hepatocellular carcinoma development and progression.

eGastroenterology Pub Date : 2025-05-04 eCollection Date: 2025-01-01 DOI:10.1136/egastro-2025-100186
Barbara Bueloni, Maite Garcia Fernandez de Barrena, Matias Antonio Avila, Juan Bayo, Guillermo Mazzolini
{"title":"Epigenetic mechanisms involved in hepatocellular carcinoma development and progression.","authors":"Barbara Bueloni, Maite Garcia Fernandez de Barrena, Matias Antonio Avila, Juan Bayo, Guillermo Mazzolini","doi":"10.1136/egastro-2025-100186","DOIUrl":null,"url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) typically develops in the context of chronic liver disease, where prolonged hepatocyte exposure to inflammation drives the synergistic accumulation of genetic and epigenetic alterations. Epigenetic regulation encompasses multiple mechanisms that govern the transcription machinery accessibility to DNA. This process is regulated by the addition and removal of covalent marks on chromatin, which can either affect DNA-histone interactions or serve as scaffolds for other proteins, among other mechanisms. Recent research has revealed that epigenetic alterations can disrupt chromatin homeostasis, redirecting transcriptional regulation to favour cancer-promoting states. Consequently, these alterations play a pivotal role in the acquisition of cancer hallmarks and provide insights into several biological processes involved in hepatocarcinogenesis. This review highlights the key epigenetic mechanisms underlying the development, progression and dissemination of HCC, with a particular focus on DNA methylation and histone post-translational modifications. This knowledge is relevant for guiding the development of innovative therapeutic approaches based on epigenetic modulators.</p>","PeriodicalId":72879,"journal":{"name":"eGastroenterology","volume":"3 2","pages":"e100186"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107448/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"eGastroenterology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/egastro-2025-100186","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Hepatocellular carcinoma (HCC) typically develops in the context of chronic liver disease, where prolonged hepatocyte exposure to inflammation drives the synergistic accumulation of genetic and epigenetic alterations. Epigenetic regulation encompasses multiple mechanisms that govern the transcription machinery accessibility to DNA. This process is regulated by the addition and removal of covalent marks on chromatin, which can either affect DNA-histone interactions or serve as scaffolds for other proteins, among other mechanisms. Recent research has revealed that epigenetic alterations can disrupt chromatin homeostasis, redirecting transcriptional regulation to favour cancer-promoting states. Consequently, these alterations play a pivotal role in the acquisition of cancer hallmarks and provide insights into several biological processes involved in hepatocarcinogenesis. This review highlights the key epigenetic mechanisms underlying the development, progression and dissemination of HCC, with a particular focus on DNA methylation and histone post-translational modifications. This knowledge is relevant for guiding the development of innovative therapeutic approaches based on epigenetic modulators.

肝细胞癌发生发展的表观遗传机制。
肝细胞癌(HCC)通常在慢性肝病的背景下发展,其中肝细胞长期暴露于炎症导致遗传和表观遗传改变的协同积累。表观遗传调控包括多种机制,控制转录机制对DNA的可及性。这一过程是通过染色质上共价标记的添加和去除来调节的,共价标记可以影响dna -组蛋白的相互作用或作为其他蛋白质的支架,以及其他机制。最近的研究表明,表观遗传改变可以破坏染色质稳态,将转录调控重定向到有利于促进癌症的状态。因此,这些改变在癌症标志的获得中起着关键作用,并为肝癌发生的几个生物学过程提供了见解。这篇综述强调了HCC发生、进展和传播的关键表观遗传机制,特别关注DNA甲基化和组蛋白翻译后修饰。这些知识对于指导基于表观遗传调节剂的创新治疗方法的发展是相关的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信