Understanding metabolic resilience by unraveling temporal dynamics of cellular responses.

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2025-05-26 DOI:10.1016/j.tem.2025.04.006

Paniz Jasbi, Alex E Mohr, Meghana Hosahalli Shivananda Murthy, Judith Klein-Seetharaman

引用次数: 0

Abstract

Metabolic resilience is essential for organismal homeostasis under diverse external pressures, because responding and adapting to stressors requires energy and drives changes at every omic level. The goal of this paper is to synthesize recent advances in understanding the intricate interplay, especially between metabolic and transcriptomic responses, involved in addressing external perturbations. We highlight the importance of timing and sequence in immediate and long-term adjustments; furthermore, we underscore the evolutionary significance of metabolic resilience and its potential for developing innovative therapeutic interventions, making it a timely contribution to contemporary biological, biomedical, and environmental research fields.

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通过揭示细胞反应的时间动态来理解代谢弹性。

代谢弹性是生物体在各种外部压力下保持体内平衡所必需的，因为对压力源的反应和适应需要能量，并在每个基因组水平上驱动变化。本文的目的是综合理解复杂的相互作用，特别是代谢和转录组反应之间的最新进展，涉及解决外部扰动。我们强调当前和长期调整的时机和顺序的重要性；此外，我们强调了代谢弹性的进化意义及其开发创新治疗干预的潜力，使其对当代生物学，生物医学和环境研究领域做出了及时的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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