New Radiopharmaceutical Tools in Imaging.

IF 4.6 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Dirk Bender
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引用次数: 0

Abstract

The strength of Nuclear Medicine imaging are the compounds to be used as radioactive probes. Unfortunately there are many constraints both in relation to physiological parameters such as metabolism as well to compound related properties like lipophilicity or chemical stability. Due these constraints, many, otherwise promising, compounds could not be used in Nuclear Medicine imaging. Within this review a brief summary is given regarding possible limitations for imaging probes and approaches or techniques to overcome the constraints. Even so the review focuses on imaging with central active compounds, many of these problems appear likewise when targeting peripheral organs. Besides the established approaches to overcome limitations some new, so far not explored, directions are discussed. Finally, a potential new tool in imaging will be presented, a trojan horse approach for transportation of radioligands. Here, like in conventional drug development, lipid nanoparticles may have potential to be used as carrier systems in Nuclear Medicine as well. This, so far not explored, concept is briefly presented.

新放射药物成像工具。
核医学成像的强度是用来作为放射性探针的化合物。不幸的是,在生理参数(如代谢)以及化合物相关特性(如亲脂性或化学稳定性)方面存在许多限制。由于这些限制,许多原本很有前途的化合物不能用于核医学成像。在这篇综述中,简要总结了成像探针和方法或技术可能存在的局限性,以克服这些局限性。尽管这篇综述关注的是中枢活性化合物的成像,但在针对外周器官时,许多问题也同样出现。除了已建立的克服局限性的方法外,还讨论了一些迄今尚未探索的新方向。最后,将介绍一种潜在的成像新工具,一种用于放射性配体运输的特洛伊木马方法。在这里,就像在传统药物开发中一样,脂质纳米颗粒也有可能被用作核医学的载体系统。这个迄今尚未探讨的概念被简要地提出。
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来源期刊
Seminars in nuclear medicine
Seminars in nuclear medicine 医学-核医学
CiteScore
9.80
自引率
6.10%
发文量
86
审稿时长
14 days
期刊介绍: Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.
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