Effectiveness of Exogenous Ketone Salts in Enhancing Circulating Acetoacetate Levels-A Pilot Study in Healthy Adults.

IF 4.8 2区医学 Q1 NUTRITION & DIETETICS

Nutrients Pub Date : 2025-05-14 DOI:10.3390/nu17101665

A Maleah Holland-Winkler, Andrew R Moore, Ilya Bederman

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引用次数: 0

Abstract

Background/objectives: Ketone salt (KS) containing a racemic beta-hydroxybutyrate mixture is commonly used as an alternative fuel source as it may lead to improved health and/or performance. We postulate that KS will raise acetoacetate levels and represent the effectiveness of exogenous KS as an energy source. We conducted a pilot study to quantify changes in the circulating acetoacetate following KS and to determine if any changes in acetoacetate were associated with the changes in circulating beta-hydroxybutyrate.

Methods: Thirteen adults (21.6 ± 4.3 years old; seven males/six females) completed this randomized, triple-blinded, placebo-controlled, cross-over design study. Participants consumed either KS or flavor-matched placebo with a one-week washout period between supplements. Blood samples were taken before and 30 min after consuming each supplement, and plasma acetoacetate and beta-hydroxybutyrate levels were measured by gas chromatography/mass spectrometry.

Results: The consumption of KS resulted in a significant increase in acetoacetate from baseline. The increase in acetoacetate after the KS supplement was significantly greater than that following the consumption of a placebo (↑ 0.57 ± 0.44 mM vs. ↑ 0.07 ± 0.23 mM, p = 0.009, d = 0.86), and significantly and strongly related to the change in blood beta-hydroxybutyrate (r = 0.757, p < 0.001).

Conclusions: Our findings indicate that KS markedly increases plasma ketone body interconversion, presumably to supply peripheral tissues for ATP generation.

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外源性酮盐提高健康成人循环乙酰乙酸水平的有效性-一项初步研究

背景/目的：含有外消旋β -羟基丁酸盐混合物的酮盐（KS）通常被用作替代燃料来源，因为它可以改善健康和/或性能。我们假设KS会提高乙酰乙酸水平，并代表外源KS作为一种能量来源的有效性。我们进行了一项初步研究，以量化在KS后循环乙酰乙酸的变化，并确定乙酰乙酸的任何变化是否与循环β -羟基丁酸的变化有关。方法：成人13例（21.6±4.3岁）；7名男性/ 6名女性)完成了这项随机、三盲、安慰剂对照的交叉设计研究。参与者食用KS或口味匹配的安慰剂，在补充之间有一周的洗脱期。在服用每种补充剂前和服用后30分钟采集血样，采用气相色谱/质谱法测定血浆乙酰乙酸酯和β -羟基丁酸水平。结果：KS的消耗导致乙酰乙酸较基线显著增加。补充KS后乙酰乙酸的增加明显大于服用安慰剂后的增加（↑0.57±0.44 mM vs↑0.07±0.23 mM, p = 0.009, d = 0.86），并且与血液中β -羟基丁酸盐的变化显著且强烈相关（r = 0.757, p < 0.001）。结论：我们的研究结果表明，KS显著增加血浆酮体相互转化，可能为外周组织提供ATP的生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.