The Antiaging Potential of Dietary Plant-Based Polyphenols: A Review on Their Role in Cellular Senescence Modulation.

IF 4.8 2区医学 Q1 NUTRITION & DIETETICS

Nutrients Pub Date : 2025-05-19 DOI:10.3390/nu17101716

Matteo Centonze, Emanuela Aloisio Caruso, Valentina De Nunzio, Miriam Cofano, Ilenia Saponara, Giuliano Pinto, Maria Notarnicola

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引用次数: 0

Abstract

Aging is a complex biological process characterized by a progressive decline in physiological functions and an increased risk of chronic diseases. A key mechanism of this process is cellular senescence, the permanent arrest of the cell cycle in response to stress or damage, which contributes to the accumulation of dysfunctional cells in tissues. Recent research has highlighted the role of polyphenols, bioactive compounds present in numerous plant-based foods, in positively modulating these processes. Polyphenols exert antioxidant effects, regulate gene expression and improve mitochondrial function, helping to delay cellular aging and prevent age-related diseases. In addition, some polyphenols exhibit senolytic properties, selectively eliminating senescent cells and promoting tissue regeneration. This review summarizes the current evidence on the effects of polyphenols on aging and cellular senescence, exploring the underlying molecular mechanisms and discussing their potential in nutritional strategies aimed at promoting healthy aging.

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膳食植物性多酚的抗衰老潜力：其在细胞衰老调节中的作用综述

衰老是一个复杂的生物学过程，其特征是生理功能的逐渐下降和慢性疾病的风险增加。这一过程的一个关键机制是细胞衰老，细胞周期因应激或损伤而永久停止，这有助于组织中功能失调细胞的积累。最近的研究强调了存在于许多植物性食物中的生物活性化合物多酚在积极调节这些过程中的作用。多酚具有抗氧化作用，调节基因表达，改善线粒体功能，有助于延缓细胞衰老，预防与年龄有关的疾病。此外，一些多酚具有抗衰老特性，选择性地消除衰老细胞，促进组织再生。本文综述了多酚对衰老和细胞衰老的影响，探讨了其潜在的分子机制，并讨论了其在促进健康衰老的营养策略中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.