An Increase of Adropin Can Predict Depression Improvement.

IF 4.8 2区医学 Q1 NUTRITION & DIETETICS

Nutrients Pub Date : 2025-05-14 DOI:10.3390/nu17101666

Duška Krnić, Sara Sablić, Maja Marinović Guić, Danijela Budimir Mršić, Dragan Krnić, Romilda Roje, Daniela Šupe Domić, Sanja Lovrić Kojundžić

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引用次数: 0

Abstract

Objectives Depression is characterized by a lack of energy, social withdrawal, and fatigue, and it is also associated with increased inflammation in the brain. Some studies suggest that adropin may have anti-inflammatory effects and could reduce the inflammatory processes contributing to depression.

Methods: We included 54 newly diagnosed patients experiencing their first episode of depression and 56 healthy volunteers in this study. The participants with depression were divided into three subgroups based on DSM-5 and BDI-II criteria. The focus of the study was to compare adropin levels between depressive patients and healthy volunteers, as well as to monitor changes in adropin levels after six months of treatment for depressive patients.

Results: Initial measurements showed no significant differences in standard laboratory parameters or adropin levels between the depression and control groups. However, adropin and vitamin D levels increased in the group of depressive patients during the six-month follow-up.

Conclusions: Our research indicates that adropin plays a significant role in the development of depression and may influence the effectiveness of depression treatments.

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Adropin的增加可以预测抑郁症的改善。

抑郁症的特征是缺乏精力、社交退缩和疲劳，并且还与大脑炎症增加有关。一些研究表明，adropin可能具有抗炎作用，可以减少导致抑郁症的炎症过程。方法：本研究纳入54例首次发病的新诊断抑郁症患者和56名健康志愿者。抑郁症患者根据DSM-5和BDI-II标准分为三个亚组。该研究的重点是比较抑郁症患者和健康志愿者之间的adropin水平，以及监测抑郁症患者治疗六个月后adropin水平的变化。结果：初步测量显示，标准实验室参数或adropin水平在抑郁症和对照组之间没有显著差异。然而，在六个月的随访中，抑郁患者组的促肾上腺素和维生素D水平有所上升。结论：adropin在抑郁症的发生发展中起着重要的作用，并可能影响抑郁症的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.