Jonathan Cornacchini, Yanis Berkane, Vlad Tereshenko, Olivier Camuzard, Alexandre G Lellouch, Elise Lupon
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引用次数: 0
Abstract
Background: Interest in microgravity is growing in the medical and surgical fields. This literature review aims to synthesize existing evidence on microgravity applications in plastic surgery, focusing on experimental methods, outcomes, and prospects.
Methods: All reported articles up to October 2023, including publications and news reports, were screened for inclusion using Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The PubMed keywords and Boolean operators were "plastic surgery AND microgravity," "plastic surgery AND spaceflight," "wound healing AND microgravity," "skin aging AND microgravity," "skin cancer AND microgravity," and "melanoma AND microgravity."
Results: A total of 201 articles were identified, and 14 studies were included. Plastic surgery procedures can be performed under microgravity, resulting in a delayed wound healing process. Four studies demonstrated that microgravity could reduce skin thickness and modify cell metabolism. In 2 studies, neoplastic melanoma cells have shown behavioral modifications under microgravity with induced apoptosis but increased potential for metastasis.
Conclusions: Microgravity represents a unique environment with potential implications in plastic surgery, although further rigorous studies need to be conducted in humans. The anticipated rise and development of spaceflights render the study of biological changes in space an impactful and significant topic.
期刊介绍：
Plastic and Reconstructive Surgery—Global Open is an open access, peer reviewed, international journal focusing on global plastic and reconstructive surgery.Plastic and Reconstructive Surgery—Global Open publishes on all areas of plastic and reconstructive surgery, including basic science/experimental studies pertinent to the field and also clinical articles on such topics as: breast reconstruction, head and neck surgery, pediatric and craniofacial surgery, hand and microsurgery, wound healing, and cosmetic and aesthetic surgery. Clinical studies, experimental articles, ideas and innovations, and techniques and case reports are all welcome article types. Manuscript submission is open to all surgeons, researchers, and other health care providers world-wide who wish to communicate their research results on topics related to plastic and reconstructive surgery. Furthermore, Plastic and Reconstructive Surgery—Global Open, a complimentary journal to Plastic and Reconstructive Surgery, provides an open access venue for the publication of those research studies sponsored by private and public funding agencies that require open access publication of study results. Its mission is to disseminate high quality, peer reviewed research in plastic and reconstructive surgery to the widest possible global audience, through an open access platform. As an open access journal, Plastic and Reconstructive Surgery—Global Open offers its content for free to any viewer. Authors of articles retain their copyright to the materials published. Additionally, Plastic and Reconstructive Surgery—Global Open provides rapid review and publication of accepted papers.
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