[Quality of life and functional outcomes in patients with rectal carcinoma].

Q4 Medicine

Nederlands tijdschrift voor geneeskunde Pub Date : 2025-05-27

Alexander J Pennings, Geraldine R Vink, Sander van Kuijk, Jarno Melenhorst, Geerard L Beets, Anne M May, Stephanie O Breukink

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引用次数: 0

Abstract

Objective: This study investigates the impact of improved diagnostics and treatments on health-related quality of life (HRQoL) and functional outcomes in patients with rectal carcinoma in the Netherlands.

Design: Data from the Prospective National ColorRectal Carcinoma cohort (PLCRC) were analysed to compare trends in HRQoL and functional outcomes between 2014 and 2019.

Method: HRQoL and functional outcomes were assessed with validated patient questionnaires (EORTC-QLQ-C30, CR29, LARS score). Longitudinal and multivariate analyses were used to analyse changes over time.

Results: Patients in 2019 had better HRQoL scores, fewer adverse events and improved anorectal function compared with 2014. Physical, role and social functioning improved significantly, while complaints such as fatigue and pain decreased. Fewer patients underwent invasive treatments or had a stoma.

Conclusion: Innovations such as population screening and less invasive treatments led to better HRQoL. Less complex therapies contributed to fewer side effects and better recovery. Further progress is expected through personalised care and innovative therapies.

本刊更多论文

[直肠癌患者的生活质量和功能结局]。

目的：本研究探讨改进诊断和治疗对荷兰直肠癌患者健康相关生活质量（HRQoL）和功能结局的影响。设计：分析来自前瞻性全国结直肠癌队列（PLCRC）的数据，以比较2014年至2019年HRQoL和功能结局的趋势。方法：采用经验证的患者问卷（EORTC-QLQ-C30、CR29、LARS评分）评估HRQoL和功能结局。使用纵向和多变量分析来分析随时间的变化。结果：与2014年相比，2019年患者HRQoL评分更好，不良事件减少，肛肠功能改善。身体、角色和社会功能显著改善，同时疲劳和疼痛等抱怨减少。接受侵入性治疗或造口的患者较少。结论：人群筛查和微创治疗等创新可提高患者的HRQoL。较少的复杂治疗有助于减少副作用和更好的恢复。通过个性化护理和创新疗法有望取得进一步进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nederlands tijdschrift voor geneeskunde Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

302

期刊介绍： Het NTVG staat bekend als hét wetenschappelijke algemene medische tijdschrift. De lange historie en de degelijkheid maken het tijdschrift tot een bolwerk van medische wetenschap in druk. Ook door de goede leesbaarheid draagt het tijdschrift bij aan de voortdurende dialoog over de geneeskunde.