Treatment outcomes in sinonasal aspergillosis in dogs in the United Kingdom: 436 cases (2011-2021).

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice Pub Date : 2025-05-28 DOI:10.1111/jsap.13876

C D Prior, H Swales, A Kortum, N Reed, M Sharman, D Kelly, A Kent, B Glanemann, K Clarke, C Lea, E Roberts, N Bommer, L Rutherford, A Tamborini, K Murphy, D J Batchelor, S Calleja, R Burrow, P M Jamieson, C Piazza, M Best, I Calvo Saiz, I Elgueta, S J Fowlie, C Shales, C Gil Morales, E Lopez, S Borgonovi, M Keane, J Kennils, E Izaguirre, M Hernandez-Perello, N Lau, A Paul, A Ridyard, E Shelton, A Farges, G Specchia, L Espada, S Spence, A Hrovat, N Van den Steen, S Tappin, T H Sparks, F Allerton

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引用次数: 0

Abstract

Objectives: A variety of treatment options for sinonasal aspergillosis have been described, encompassing non-invasive and invasive approaches. To describe the clinical outcomes in dogs treated for sinonasal aspergillosis in the United Kingdom.

Materials and methods: A multi-centre retrospective survey was performed involving 23 referral centres in the United Kingdom from January 2011 to December 2021. Cases were reviewed for first treatment success rates, the number of treatments required and overall clinical remission rates. Different treatment approaches were compared, including rhinoscopic debridement (RD), trephination (TR) and sinusotomy/rhinotomy (SR).

Results: In a cohort of 436 dogs with sinonasal aspergillosis, the most common first treatment modalities were RD (38%) and TR (32%), with SR used in 7% and oral antifungal monotherapy in 3%. The remaining 20% used a mixture of treatments. First treatment remission rate was 55% with SR, 38% with RD, 29% with TR and 31% with the mixed treatment. Overall remission rate was 67% with SR, 81% with RD and 69% with TR and 59% where different treatments were combined. Oral antifungal monotherapy had no successful outcomes at any time point. Complete debridement significantly improved remission rates of first treatments (54% vs. 21%, P = 0.003). Adverse effects were reported in 24% of cases, most commonly in SR and TR groups.

Clinical significance: Rhinoscopic debridement and trephination remain the predominant treatment options for SNA in UK referral practices, with similar overall clinical remission rates. The degree of debridement significantly influences treatment outcomes, with rhinoscopic debridement in combination with topical antifungals showing the highest success rates.

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英国犬鼻曲霉病的治疗结果：436例（2011-2021）。

目的：鼻窦曲霉病的多种治疗方案已被描述，包括非侵入性和侵入性方法。描述在英国治疗鼻曲霉病的狗的临床结果。材料和方法：2011年1月至2021年12月，对英国23个转诊中心进行了多中心回顾性调查。病例回顾了首次治疗的成功率，所需治疗的数量和总体临床缓解率。比较不同的治疗方法，包括鼻镜清创（RD），钻孔（TR）和鼻窦切开术/鼻切开术（SR）。结果：在436只鼻曲霉病狗的队列中，最常见的首次治疗方式是RD（38%）和TR (32%)， SR占7%，口服抗真菌单药治疗占3%。剩下的20%使用混合疗法。首次治疗缓解率SR组为55%，RD组为38%，TR组为29%，混合治疗组为31%。SR组总缓解率为67%，RD组为81%，TR组为69%，不同治疗联合组为59%。口服抗真菌单药治疗在任何时间点都没有成功的结果。完全清创可显著提高首次治疗的缓解率（54%对21%，P = 0.003）。24%的病例报告了不良反应，最常见于SR组和TR组。临床意义：在英国转诊实践中，鼻镜清创和钻孔术仍然是SNA的主要治疗选择，总体临床缓解率相似。清创程度显著影响治疗结果，鼻镜清创联合局部抗真菌药物成功率最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Small Animal Practice 农林科学-兽医学

CiteScore

3.30

自引率

6.20%

发文量

117

审稿时长

12-24 weeks

期刊介绍： Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery. In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world. The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher. The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association