The interaction between the expression of CD23 molecule on B- lymphocytes and the level of specific IgE against molecular components of pollen in atopic dermatitis patients with and without dupilumab therapy.

IF 3.1 4区 医学 Q3 TOXICOLOGY
Journal of Immunotoxicology Pub Date : 2025-12-01 Epub Date: 2025-05-28 DOI:10.1080/1547691X.2025.2507311
J Čelakovská, E Čermáková, P Boudková
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引用次数: 0

Abstract

The aim of the study here was to evaluate the association between expression of CD23 molecule on B-lymphocytes and the level of specific IgE to molecular components of birch, Bermuda grass, hazel pollen, timothy, and rye grass in atopic dermatitis (AD) patients (with and without dupilumab therapy). A total of 46 patients suffering from AD were included: 26 without dupilumab treatment and 20 with dupilumab treatment. Serum levels of specific IgE were measured by the components resolved diagnostic assay ALEX2 Allergy Xplorer, the expression of CD23 molecule on B-lymphocytes was evaluated with flow cytometry. For the statistical analysis, the Spearman's rank correlation coefficient was used. In patients treated with dupilumab, the higher association was observed between the expression of CD23 on B-lymphocytes and specific IgE to molecular components Bet v 1, Cor a 1.0103, Cor a 1.0401, and Phl p 1. This study demonstrated that the relationship between CD23 expression on B-lymphocytes and specific IgE to pollen molecular components varies depending on whether the patient was treated with dupilumab and the type of molecular component involved.

特应性皮炎患者接受或不接受dupilumab治疗时B淋巴细胞CD23分子表达与特异性IgE水平的相互作用
本研究的目的是评估特应性皮炎(AD)患者(接受或不接受dupilumab治疗)中b淋巴细胞上CD23分子表达与桦树、百慕大草、榛花粉、提莫西草和黑麦草分子成分特异性IgE水平之间的关系。共纳入46例AD患者:26例未接受dupilumab治疗,20例接受dupilumab治疗。采用成分分解诊断法ALEX2 Allergy Xplorer检测血清特异性IgE水平,采用流式细胞术检测b淋巴细胞CD23分子表达。统计分析采用Spearman等级相关系数。在接受dupilumab治疗的患者中,观察到b淋巴细胞上CD23的表达与特异性IgE对分子成分Bet v1, Cor a 1.0103, Cor a 1.0401和Phl p1的相关性更高。本研究表明,b淋巴细胞上CD23表达与特异性IgE对花粉分子成分的关系取决于患者是否使用杜匹单抗以及所涉及的分子成分类型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Immunotoxicology
Journal of Immunotoxicology 医学-毒理学
CiteScore
6.70
自引率
3.00%
发文量
26
审稿时长
1 months
期刊介绍: The Journal of Immunotoxicology is an open access, peer-reviewed journal that provides a needed singular forum for the international community of immunotoxicologists, immunologists, and toxicologists working in academia, government, consulting, and industry to both publish their original research and be made aware of the research findings of their colleagues in a timely manner. Research from many subdisciplines are presented in the journal, including the areas of molecular, developmental, pulmonary, regulatory, nutritional, mechanistic, wildlife, and environmental immunotoxicology, immunology, and toxicology. Original research articles as well as timely comprehensive reviews are published.
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