Oocyte and zygote development potential in minimal stimulation, natural cycle and conventionally stimulated IVF: an international multi-centre retrospective cohort study.

IF 2.7 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2025-05-28 DOI:10.1007/s10815-025-03508-3

Isotta Martha Magaton, Ikbale Siercks, Martina Nordin, Roxana Maria Popovici, Eva Maria Boogen, Stefan Eisenhardt, Natalie Reeka, Jan-Simon Lanowski, Marie Roumet, Michael von Wolff

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引用次数: 0

Abstract

Purpose: The aim of this research is to assess the development potential of oocytes and zygotes obtained from Natural cycle IVF (NC-IVF), different minimal stimulation IVF (Min stim-IVF) and conventionally stimulated IVF (cIVF) treatment protocols.

Methods: International multi-centre retrospective cohort study including 1483 NC-IVF, 1208 Min stim-IVF, and 1892 cIVF cycles performed in 8 IVF centres between 01.2022 and 03.2023. The five Min stim-IVF protocols analysed included low dose clomiphene citrate, aromatase inhibitors, low dose (≤ 100 IU) gonadotropins, each alone or in combination. For each IVF protocol, we assessed and modelled the transition probabilities of (i) each observed oocyte developing into a zygote, (ii) each observed zygote developing into a gestational sac and (iii) each observed zygote developing into a live birth.

Results: All modelled transition probabilities were found to be maximal in NC-IVF, minimal in cIVF with Min stim-IVF in between. The probability of transition from oocyte to zygote was 0.72 for NC-IVF, 0.56 to 0.65 for Min stim-IVF protocols and 0.54 for cIVF. The probability of transition from zygote to gestational sac was 0.21 for NC-IVF, 0.14 to 0.19 for Min stim-IVF and 0.09 for cIVF protocols and from zygote to live birth 0.16 for NC-IVF, 0.09 to 0.16 for Min stim-IVF and 0.06 for cIVF protocols.

Conclusions: The transition probabilities of oocytes and zygotes appears to be higher in NC-IVF, followed by Min stim-IVF and then cIVF, suggesting that increasing dosages of gonadotropins might have a negative effect on oocyte/zygote development potential.

Trial registration: Clinicaltrial.gov: NCT05125497. Registration date 03.11.2021.

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最小刺激、自然周期和常规刺激的IVF中卵母细胞和受精卵发育潜力：一项国际多中心回顾性队列研究。

目的：本研究的目的是评估自然周期体外受精（NC-IVF）、不同最小刺激体外受精（Min -IVF）和常规刺激体外受精（cIVF）治疗方案获得的卵母细胞和受精卵的发育潜力。方法：国际多中心回顾性队列研究，包括在2022年1月1日至2023年3月期间在8个IVF中心进行的1483个NC-IVF， 1208个Min -IVF和1892个cIVF周期。分析的5种Min刺激- ivf方案包括低剂量克罗米芬柠檬酸盐、芳香酶抑制剂、低剂量（≤100 IU）促性腺激素，单独或联合使用。对于每个试管婴儿方案，我们评估并模拟了(i)每个观察到的卵母细胞发育成受精卵，（ii）每个观察到的受精卵发育成妊娠囊和（iii）每个观察到的受精卵发育成活产儿的过渡概率。结果：所有模型的转移概率在NC-IVF中最大，在cIVF中最小，在两者之间最小。NC-IVF方案从卵母细胞过渡到受精卵的概率为0.72，Min - ivf方案为0.56 ~ 0.65，cIVF方案为0.54。NC-IVF从受精卵过渡到妊娠囊的概率为0.21，Min - ivf为0.14 ~ 0.19，cIVF为0.09；NC-IVF从受精卵过渡到活产的概率为0.16，Min - ivf为0.09 ~ 0.16，cIVF为0.06。结论：NC-IVF中卵母细胞和受精卵的转移概率较高，Min - ivf次之，cIVF次之，提示增加促性腺激素剂量可能对卵母细胞/受精卵的发育潜力有负面影响。试验注册：Clinicaltrial.gov: NCT05125497。注册日期：2021年11月3日。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.