Austin Lowery, Yanfang Peipei Zhu, Catherine C Hedrick
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引用次数: 0
Abstract
Neutrophils are traditionally known as short-lived pathogen-killing cells, but recent work published in Nature by Hidalgo and colleagues uncovers a novel role for neutrophils in maintaining skin integrity. Using transcriptomics, imaging, and genetic models, the study reveals that skin-infiltrating neutrophils produce collagen, particularly COL3A1, to regulate tissue mechanics and form matrix-rich "shields" that prevent pathogen entry. Collagen production by these specialized neutrophils in the skin was TGFβ-dependent and essential for wound protection, as its disruption led to disorganized skin architecture and increased bacterial invasion. This work redefines neutrophils as dynamic matrix-builders in barrier tissues, offering new insights into immune-tissue crosstalk and advancing our understanding of wound healing and host defense.
期刊介绍：
JLB is a peer-reviewed, academic journal published by the Society for Leukocyte Biology for its members and the community of immunobiologists. The journal publishes papers devoted to the exploration of the cellular and molecular biology of granulocytes, mononuclear phagocytes, lymphocytes, NK cells, and other cells involved in host physiology and defense/resistance against disease. Since all cells in the body can directly or indirectly contribute to the maintenance of the integrity of the organism and restoration of homeostasis through repair, JLB also considers articles involving epithelial, endothelial, fibroblastic, neural, and other somatic cell types participating in host defense. Studies covering pathophysiology, cell development, differentiation and trafficking; fundamental, translational and clinical immunology, inflammation, extracellular mediators and effector molecules; receptors, signal transduction and genes are considered relevant. Research articles and reviews that provide a novel understanding in any of these fields are given priority as well as technical advances related to leukocyte research methods.
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