Exploring the Multifunctional Role of Alpha-Fetoprotein in Cancer Progression: Implications for Targeted Therapy in Hepatocellular Carcinoma and Beyond.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-05-19 DOI:10.3390/ijms26104863

Hyunjung Kim, Minji Jang, Eunmi Kim

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引用次数: 0

Abstract

Alpha-fetoprotein (AFP) is a well-known biomarker for liver cancer, and its clinical utility is widely recognized. Recent studies have revealed that AFP plays a multifaceted role in various malignant tumors, including liver cancer. This suggests that AFP is not merely a biomarker but also contributes significantly to the complex process of tumor formation, emphasizing the importance of targeting AFP in therapeutic approaches. Consequently, innovative research and development are essential to overcome the current limitations of AFP-targeted therapies, enhance treatment efficacy, and minimize side effects. This review explores the role of AFP in cancer development and progression, highlights the biological functions of AFP and related pathways, and discusses the clinical implications of AFP-targeted therapies. Ongoing research on AFP will significantly contribute to our understanding of the biological mechanisms of cancer and aid in developing effective and safe treatments. Ultimately, advancements in AFP-targeted therapeutic approaches are expected to play a crucial role in the future of cancer management.

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探索甲胎蛋白在癌症进展中的多功能作用：肝细胞癌及其他疾病靶向治疗的意义。

甲胎蛋白（AFP）是一种众所周知的肝癌生物标志物，其临床应用已得到广泛认可。最近的研究表明，AFP在包括肝癌在内的多种恶性肿瘤中起着多方面的作用。这表明AFP不仅是一种生物标志物，而且对肿瘤形成的复杂过程也有重要贡献，强调了靶向AFP在治疗方法中的重要性。因此，创新的研究和开发对于克服目前afp靶向治疗的局限性、提高治疗效果和减少副作用至关重要。本文综述了AFP在癌症发生发展中的作用，重点介绍了AFP的生物学功能和相关途径，并讨论了AFP靶向治疗的临床意义。正在进行的AFP研究将极大地促进我们对癌症生物学机制的理解，并有助于开发有效和安全的治疗方法。最终，afp靶向治疗方法的进步有望在未来的癌症治疗中发挥关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Molecular Sciences 化学-化学综合

自引率

10.70%

发文量

13472

审稿时长

1.7 months

期刊介绍： The International Journal of Molecular Sciences (ISSN 1422-0067) provides an advanced forum for chemistry, molecular physics (chemical physics and physical chemistry) and molecular biology. It publishes research articles, reviews, communications and short notes. Our aim is to encourage scientists to publish their theoretical and experimental results in as much detail as possible. Therefore, there is no restriction on the length of the papers or the number of electronics supplementary files. For articles with computational results, the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material (including animated pictures, videos, interactive Excel sheets, software executables and others).