Laura Murcia-Flores, Ana Sánchez-García, María Pilar Pecci-Lloret, Francisco Javier Rodríguez-Lozano
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引用次数: 0
Abstract
The oral cavity serves as the gateway to the human organism, hosting a diverse community of microorganisms that coexist in a state of symbiosis. Disruption of this balance leads to oral dysbiosis, a condition associated with infections and oral pathologies, which may contribute to the etiopathogenesis of systemic disorders such as Parkinson's disease, a neurodegenerative movement disorder characterized by resting tremor, rigidity, and bradykinesia. While oral dysbiosis is recognized as a risk factor and an aggravating element for Parkinson's disease, it is not regarded as a direct cause. This systematic review aims to synthesize existing research exploring the potential relationship between oral dysbiosis and the development of Parkinson's disease. Following a comprehensive analysis, 12 studies were selected, comprising 11 case-control studies and one observational analytical study. These studies investigated the composition of oral microbiota in different sample groups, revealing a higher abundance of pathogenic oral bacteria in individuals diagnosed with Parkinson's disease. The findings suggest that oral dysbiosis may influence both the onset of Parkinson's disease and the progression of symptoms such as cognitive decline. These results pave the way for future research, particularly regarding alterations in oral microbiota as potential biomarkers for early diagnosis and disease monitoring.
期刊介绍：
Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.
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