Real-world use of a hydrophilic curcumin-based oral formulation in the management of macular oedema: a collection of clinical experiences.

IF 2.8 Q2 Pharmacology, Toxicology and Pharmaceutics
Drugs in Context Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI:10.7573/dic.2025-3-3
Davide Allegrini, Giuseppe Covello, Alessandra Mancini, Antonino Mancini, Maura Mancini, Mary Romano, Aldo Vecchiarelli, Mario R Romano
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引用次数: 0

Abstract

This is a collection of clinical experiences exploring the real-world effectiveness of a hydrophilic curcumin-based oral formulation (CHC, Diabec®) in the management of macular oedema across diverse retinal conditions, including diabetic macular oedema, central serous chorioretinopathy, branch retinal vein occlusion and Irvine-Gass syndrome. Eight cases reported significant improvements in best-corrected visual acuity and central macular thickness, with complete resolution of oedema in some instances. CHC was well tolerated, with no adverse effects reported. These findings suggest that CHC is a safe and effective adjunct or standalone therapy for chronic or refractory macular oedema, enhancing anatomical and functional outcomes in real-world settings.

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实际使用的亲水性姜黄素为基础的口服制剂在黄斑水肿的管理:临床经验的集合。
这是一项临床经验的集合,探索基于亲水姜黄素的口服制剂(CHC, Diabec®)在各种视网膜疾病(包括糖尿病性黄斑水肿、中央浆液性脉络膜视网膜病变、视网膜分支静脉闭塞和Irvine-Gass综合征)治疗黄斑水肿的实际有效性。8例患者的最佳矫正视力和中央黄斑厚度均有显著改善,部分患者水肿完全消失。CHC耐受性良好,无不良反应报道。这些研究结果表明,CHC是一种安全有效的慢性或难治性黄斑水肿辅助或独立治疗方法,可改善现实环境中的解剖和功能结果。
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来源期刊
Drugs in Context
Drugs in Context Medicine-Medicine (all)
CiteScore
5.90
自引率
0.00%
发文量
63
审稿时长
9 weeks
期刊介绍: Covers all phases of original research: laboratory, animal and human/clinical studies, health economics and outcomes research, and postmarketing studies. Original research that shows positive or negative results are welcomed. Invited review articles may cover single-drug reviews, drug class reviews, latest advances in drug therapy, therapeutic-area reviews, place-in-therapy reviews, new pathways and classes of drugs. In addition, systematic reviews and meta-analyses are welcomed and may be published as original research if performed per accepted guidelines. Editorials of key topics and issues in drugs and therapeutics are welcomed. The Editor-in-Chief will also consider manuscripts of interest in areas such as technologies that support diagnosis, assessment and treatment. EQUATOR Network reporting guidelines should be followed for each article type. GPP3 Guidelines should be followed for any industry-sponsored manuscripts. Other Editorial sections may include Editorial, Case Report, Conference Report, Letter-to-the-Editor, Educational Section.
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