Bibliometrics Analysis and Knowledge Mapping of Fragment-Based Drug Design Research: Trends from 2015 to 2024.

IF 4.7 2区医学 Q1 CHEMISTRY, MEDICINAL

Drug Design, Development and Therapy Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI:10.2147/DDDT.S518489

Chenming He, Jirong Zhang, Runze Zhang, Liang Liu, Jielian Luo, Wen Zhang, Bangjiang Fang

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引用次数: 0

Abstract

Purpose: This study systematically analyzed available literature related to fragment-based drug design (FBDD) published between 2015 and 2024 using bibliometric methods to identify research trends, hotspots, and emerging frontiers. The findings provide valuable information and a comprehensive reference for future FBDD research and drug development.

Methods: The relevant literature was comprehensively searched from the Web of Science Core Collection (WOSCC) database using the keywords "Fragment-based drug design" or "FBDD", covering articles published between January 1, 2015 and November 1, 2024. A total of 1,301 papers were included. Bibliometric analysis and knowledge mapping were conducted using the RStudio's bibliometrix-biblioshiny package, CiteSpace, and VOSviewer software, assessing multiple dimensions such as journal co-occurrence, keyword density, institutional collaboration, and citation patterns.

Results: The research output in FBDD revealed fluctuating growth, with an average annual growth rate of 1.42%. The United States and China lead global research with 889 and 719 publications, respectively, contributing significantly to international collaboration (34.82%). Prominent research institutions included the Center National de la Recherche Scientifique (CNRS), the University of Cambridge, and the Chinese Academy of Sciences, demonstrating strong academic influence. Key contributors such as Abell, C. Blundell, TL, and Johnson, CN, were among the top ten high-impact authors, significantly shaping the FBDD landscape through highly cited publications. Influential journals included the Journal of Medicinal Chemistry, Journal of Chemical Information and Modeling, and the European Journal of Medicinal Chemistry, each highly recognized within the FBDD research community. Keyword analysis indicated core research directions focused on "fragment-based drug discovery", "molecular docking", and "drug discovery", reflecting key technological advancements and research hotspots.

Conclusion: FBDD remains a dynamic field with ongoing global academic attention. Future research directions are likely to emphasize innovations in computational simulation, targeted drug screening, and molecular docking techniques, facilitating the advancement and development of novel therapeutic agents.

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基于片段的药物设计研究的文献计量学分析和知识图谱：2015 - 2024年的趋势。

目的：采用文献计量学方法，系统分析2015 - 2024年间发表的基于片段的药物设计（fragment-based drug design， FBDD）相关文献，识别研究趋势、热点和新兴前沿。这些发现为今后FBDD的研究和药物开发提供了有价值的信息和全面的参考。方法：以“Fragment-based drug design”或“FBDD”为关键词，在Web of Science Core Collection （WOSCC）数据库中全面检索相关文献，检索时间为2015年1月1日至2024年11月1日。共收录论文1301篇。使用RStudio的bibliometrix-biblioshiny软件包、CiteSpace和VOSviewer软件进行文献计量分析和知识图谱，评估期刊共现、关键词密度、机构合作和引文模式等多个维度。结果：FBDD的研究产出呈现波动增长，年均增长率为1.42%。美国和中国分别以889篇和719篇出版物引领全球研究，对国际合作贡献显著（34.82%）。法国国家科学研究中心（CNRS）、英国剑桥大学、中国科学院等知名研究机构在中国具有强大的学术影响力。Abell， C. Blundell， TL和Johnson， CN等主要贡献者是十大高影响力作者之一，他们通过高引用的出版物显著地塑造了FBDD的格局。有影响力的期刊包括《Journal of Medicinal Chemistry》、《Journal of Chemical Information and Modeling》和《European Journal of Medicinal Chemistry》，这些期刊在FBDD研究界都得到了高度认可。关键词分析表明，核心研究方向集中在“基于片段的药物发现”、“分子对接”和“药物发现”，反映了关键技术进展和研究热点。结论：FBDD仍然是一个充满活力的领域，受到全球学术界的持续关注。未来的研究方向可能会强调在计算模拟、靶向药物筛选和分子对接技术方面的创新，促进新型治疗剂的进步和发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.