Ashley Crouch, Aysha Chaudhri, Sonya Khan, Maggie Ma, Ngoc Vu, William Towers
{"title":"Acute Management of Hypercalcemia of Malignancy - A Review of Pathophysiology, Diagnosis, and Treatment.","authors":"Ashley Crouch, Aysha Chaudhri, Sonya Khan, Maggie Ma, Ngoc Vu, William Towers","doi":"10.1007/s11912-025-01685-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Hypercalcemia of malignancy is one of the most common metabolic disorders in patients with cancer and is associated with significant morbidity and mortality. This narrative review summarizes pathophysiology, clinical presentation, diagnostic strategies, and therapies available for the management of hypercalcemia of malignancy in acutely ill adult patients.</p><p><strong>Recent findings: </strong>We reviewed both classic and recent literature to provide practical recommendations for managing cancer-related hypercalcemia. Our findings are presented in the context of recently published societal guidelines. Timely identification and treatment of acute hypercalcemia of malignancy is vital. Understanding of the underlying disease processes and available therapies is needed to optimize patient care and healthcare resource utilization.</p>","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Oncology Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11912-025-01685-z","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: Hypercalcemia of malignancy is one of the most common metabolic disorders in patients with cancer and is associated with significant morbidity and mortality. This narrative review summarizes pathophysiology, clinical presentation, diagnostic strategies, and therapies available for the management of hypercalcemia of malignancy in acutely ill adult patients.
Recent findings: We reviewed both classic and recent literature to provide practical recommendations for managing cancer-related hypercalcemia. Our findings are presented in the context of recently published societal guidelines. Timely identification and treatment of acute hypercalcemia of malignancy is vital. Understanding of the underlying disease processes and available therapies is needed to optimize patient care and healthcare resource utilization.
期刊介绍:
This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer.
We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.