Ashley Matusz-Fisher, Annabel Chen, Erin E Donahue, Courtney R Schepel, Michelle L Wallander, Chad A Livasy, Richard L White, Antoinette R Tan, Lejla Hadzikadic-Gusic
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引用次数: 0
Abstract
Purpose: Metaplastic breast cancer (MpBC) is a rare, aggressive type of breast cancer composed of several histologic patterns. This study evaluated outcomes among the MpBC histologic patterns, which include spindle cell/sarcomatous, squamous, heterologous mesenchymal, and mixed.
Patients and methods: A retrospective chart review identified patients with early-stage MpBC diagnosed between January 1, 2010, and September 1, 2021. A matched control patient cohort with nonmetaplastic triple-negative breast cancer (TNBC) was selected. Associations between MpBC histologic patterns and disease characteristics were evaluated using chi-squared and Wilcoxon tests. Kaplan-Meier estimates and log rank tests assessed differences in recurrence-free survival (RFS) and overall survival (OS).
Results: In the MpBC cohort (n = 106), histologic patterns included spindle cell/sarcomatous (34%), squamous (16%), heterologous mesenchymal (31%), mixed (18%), and other (1%). In patients with MpBC who received neoadjuvant chemotherapy (n = 32), residual cancer burden (RCB) was not found to be significantly different between the spindle cell/sarcomatous pattern versus other patterns (P = .81). In the entire MpBC cohort, patients with the spindle cell/sarcomatous pattern had inferior RFS (P = .02) and OS (P = .004) compared to patients with other patterns. There was no significant difference in RFS (P = .90) or OS (P = .90) between the MpBC and TNBC cohort.
Conclusion: RCB did not differ among the MpBC histologic patterns, but outcomes were inferior in patients with the spindle cell/sarcomatous pattern. Outcomes were also inferior in patients with MpBC receiving neoadjuvant versus adjuvant chemotherapy. Our study did not find a difference in outcomes between patients with MpBC versus nonmetaplastic TNBC. More investigation with larger sample sizes and biomarkers is warranted.
期刊介绍：
Clinical Breast Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of breast cancer. Clinical Breast Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of breast cancer. The main emphasis is on recent scientific developments in all areas related to breast cancer. Specific areas of interest include clinical research reports from various therapeutic modalities, cancer genetics, drug sensitivity and resistance, novel imaging, tumor genomics, biomarkers, and chemoprevention strategies.
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