An Activation Likelihood Estimation Meta-Analysis of Voxel-Based Morphometry Studies of Chemotherapy-Related Brain Volume Changes in Breast Cancer.

IF 4.5 2区医学 Q1 ONCOLOGY

Cancers Pub Date : 2025-05-16 DOI:10.3390/cancers17101684

Sonya Utecht, Horacio Gomez-Acevedo, Jonathan Bona, Ellen van der Plas, Fred Prior, Linda J Larson-Prior

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引用次数: 0

Abstract

Background/objectives: Breast cancer chemotherapy patients and survivors face cognitive side effects that are not fully understood. Neuroimaging can provide a unique way to study these effects; however, it can be difficult to recruit large numbers of subjects. Our meta-analysis aims to synthesize volumetric neuroimaging data to highlight consistent findings in regional brain volume changes to further advance our understanding of the chemotherapy-related cognitive impairments faced by breast cancer patients and survivors.

Methods: An Activation Likelihood Estimation analysis was conducted across the data from eight voxel-based morphometry experiments examining changes in the brains of breast cancer patients and survivors exposed to chemotherapy over time and three voxel-based morphometry experiments comparing chemotherapy-exposed subjects to controls with and without breast cancer.

Results: There were consistent volume reductions across the whole brain in both experiment groups. The subjects' over-time analysis showed peak consistency among the studies in the right inferior frontal gyrus and the left insula.

Conclusions: Chemotherapy for non-central nervous system cancers such as breast cancer can cause physical changes throughout the brain that can be quantitatively measured by neuroimaging methodologies and may underlie persistent cognitive deficits in some individuals.

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乳腺癌化疗相关脑容量变化体素形态学研究的激活似然估计meta分析。

背景/目的：乳腺癌化疗患者和幸存者面临认知副作用尚未完全了解。神经影像学可以提供一种独特的方法来研究这些影响；然而，招募大量受试者可能很困难。我们的荟萃分析旨在综合体积神经成像数据，以突出区域脑容量变化的一致发现，从而进一步推进我们对乳腺癌患者和幸存者面临的化疗相关认知障碍的理解。方法：对8个基于体素的形态学实验的数据进行激活似然估计分析，这些实验研究了乳腺癌患者和化疗幸存者随着时间的推移的大脑变化，以及3个基于体素的形态学实验，比较化疗暴露的受试者与患有和未患乳腺癌的对照组。结果：在两个实验组中，整个大脑的体积都有一致的减少。受试者的长期分析显示，研究结果在右侧额下回和左侧脑岛的一致性最高。结论：非中枢神经系统癌症（如乳腺癌）的化疗可引起整个大脑的物理变化，这些变化可通过神经影像学方法定量测量，并且可能是某些个体持续认知缺陷的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancers Medicine-Oncology

CiteScore

8.00

自引率

9.60%

发文量

5371

审稿时长

18.07 days

期刊介绍： Cancers (ISSN 2072-6694) is an international, peer-reviewed open access journal on oncology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.