Gut microbiota and relevant metabolites analysis in perianal abscess of infants.

IF 4 2区生物学 Q2 MICROBIOLOGY

BMC Microbiology Pub Date : 2025-05-28 DOI:10.1186/s12866-025-04020-5

Shuai Wang, Jingfeng Zhang, Mingfeng Fan, Zhenmei Dong, Laian Li, Juan Xu, Wanbin Yin, Xiangjun Xu

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引用次数: 0

Abstract

Objectives: To explore the characteristics of the gut microbiota and metabolites in infants with perianal abscess compared with healthy infants, thereby providing a reference for treating perianal abscess in infants.

Methods: The gut microbiota of 19 infants with perianal abscess and 21 healthy infants were compared using 16S rRNA gene sequencing. Metabolite compositions were compared between a subset of 16 infants with perianal abscess and 8 healthy infants.

Results: Both groups showed significant differences in the abundance of the genera Ruminococcus (P = 0.002) and Parasutterella (P = 0.004). Five metabolic pathways, namely, steroid biosynthesis, one-carbon pool by folate, synthesis, secretion, and action of the parathyroid hormone, cholesterol metabolism, and tuberculosis, were significantly enriched. Three metabolites, namely, calcidiol, dihydrofolic acid, and taurochenodesoxycholic acid, were involved in these enriched pathways.

Conclusion: The study revealed significant differences in the composition of the gut microbiota and metabolites between healthy infants and those with perianal abscess, suggesting a potential association between the gut microbiota and infantile perianal abscess.

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婴儿肛周脓肿的肠道菌群及相关代谢物分析。

目的：探讨婴幼儿肛周脓肿与健康婴幼儿肠道菌群及代谢物的差异，为婴幼儿肛周脓肿的治疗提供参考。方法：采用16S rRNA基因测序法对19例肛周脓肿患儿和21例健康患儿的肠道菌群进行比较。比较了16例肛周脓肿婴儿和8例健康婴儿的代谢物组成。结果：两组Ruminococcus属（P = 0.002）和Parasutterella属（P = 0.004）的丰度有显著差异。类固醇生物合成、叶酸单碳库、甲状旁腺激素的合成、分泌和作用、胆固醇代谢、结核等5条代谢途径显著增加。三种代谢物，即钙二醇、二氢叶酸和牛磺酸去氧胆酸，参与了这些富集途径。结论：该研究揭示了健康婴儿和肛周脓肿婴儿肠道微生物群组成和代谢物的显著差异，提示肠道微生物群与婴儿肛周脓肿之间存在潜在关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Microbiology 生物-微生物学

CiteScore

7.20

自引率

0.00%

发文量

280

审稿时长

3 months

期刊介绍： BMC Microbiology is an open access, peer-reviewed journal that considers articles on analytical and functional studies of prokaryotic and eukaryotic microorganisms, viruses and small parasites, as well as host and therapeutic responses to them and their interaction with the environment.