Correlation of PET/CT Maximal Standardized Uptake Values with Clinicopathologic Parameters of Aggressive Non-Hodgkin's Lymphoma.

IF 2.5 4区医学 Q3 ONCOLOGY

Cancer Management and Research Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI:10.2147/CMAR.S522628

Yingci Li, Dongbo Wu, Mohan Tian

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引用次数: 0

Abstract

Objective: To investigate the correlation between the maximum standardized uptake value (SUV_max) of positron emission tomography (PET)/computed tomography (CT) scanning imaging with the clinicopathologic parameters of aggressive non-Hodgkin's lymphoma (NHL) and its diagnostic value.

Methods: A total of 128 patients with NHL were retrospectively selected. PET/CT examination was performed to calculate SUV_max, and clinicopathological data were collected. Pearson correlation test was used to analyze the correlation between them, and the relevant indicators were detected according to the pathological results. ROC curve was used to analyze the diagnostic value.

Results: The level of PET/CT SUV_max was positively correlated with the levels of β2-microglobulin (β2-MG), lactate dehydrogenase (LDH), Ki-67, tumor size and bone marrow infiltration (P<0.05). The PET/CT SUV_max and serum β2-MG, LDH and Ki-67 levels in the aggressive group were significantly higher than those in the indolent group (P<0.05). The AUC of the combined detection of PET/CT SUV_max, β2-MG, LDH and Ki-67 in the diagnosis of aggressive NHL was 0.920, and the combined detection had a high diagnostic value.

Conclusion: PET/CT SUV_max was correlated with a variety of clinicopathological parameters. Combined detection of PET/CT SUV_max has high diagnostic value in aggressive NHL.

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侵袭性非霍奇金淋巴瘤PET/CT最大标准化摄取值与临床病理参数的相关性

目的：探讨侵袭性非霍奇金淋巴瘤（NHL）的正电子发射断层扫描(PET)/计算机断层扫描（CT）扫描成像的最大标准化摄取值（SUVmax）与临床病理参数的相关性及其诊断价值。方法：回顾性分析128例非霍奇金淋巴瘤患者。进行PET/CT检查计算SUVmax，并收集临床病理资料。采用Pearson相关检验分析两者之间的相关性，并根据病理结果检测相关指标。采用ROC曲线分析诊断价值。结果：PET/CT SUVmax水平与β2-微球蛋白（β2-MG）、乳酸脱氢酶（LDH）、Ki-67、肿瘤大小及骨髓浸润水平呈正相关(Pmax及血清β2-MG、LDH、Ki-67水平在侵袭性NHL诊断中的意义显著高于无为组（Pmax、β2-MG、LDH、Ki-67诊断价值为0.920），联合检测具有较高的诊断价值。结论：PET/CT SUVmax与多种临床病理参数相关。PET/CT SUVmax联合检测对侵袭性NHL有较高的诊断价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Management and Research Medicine-Oncology

CiteScore

7.40

自引率

0.00%

发文量

448

审稿时长

16 weeks

期刊介绍： Cancer Management and Research is an international, peer reviewed, open access journal focusing on cancer research and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival, and quality of life for cancer patients. Specific topics covered in the journal include: ◦Epidemiology, detection and screening ◦Cellular research and biomarkers ◦Identification of biotargets and agents with novel mechanisms of action ◦Optimal clinical use of existing anticancer agents, including combination therapies ◦Radiation and surgery ◦Palliative care ◦Patient adherence, quality of life, satisfaction The journal welcomes submitted papers covering original research, basic science, clinical & epidemiological studies, reviews & evaluations, guidelines, expert opinion and commentary, and case series that shed novel insights on a disease or disease subtype.