A case of Corynebacterium propinquum microbial keratitis after amniotic membrane transplantation.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

BMC Ophthalmology Pub Date : 2025-05-27 DOI:10.1186/s12886-025-04159-9

Yuto Yukari, Toshiki Shimizu, Takahiko Hayashi, Yusuke Hara, Ami Igarashi, Satoru Yamagami

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引用次数: 0

Abstract

Background: Amniotic membrane transplantation (AMT) is a relatively safe procedure with few complications. Postoperatively, patients are treated with topical antibacterial eye drops. However, even antibacterial drug administration cannot completely prevent antimicrobial-resistant keratitis. This paper presents a case of Corynebacterium propinquum keratitis associated with AMT.

Case presentation: An 84-year-old female patient who underwent AMT for bullous keratopathy developed keratitis with colony formation on the transplanted amniotic membrane graft 45 days postoperatively. The colony was scraped, cultured, and identified as C. propinquum using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Subsequently, topical treatment improved the infection while relieving the pain.

Conclusion: To the best of our knowledge, this is the first reported case of C. propinquum keratitis associated with amniotic membrane grafts. Although AMT is a relatively safe procedure with few complications, careful observation is required to diagnose and treat possible postoperative infection. Immunosuppressed patients, including those post-AMT, may suffer from antimicrobial-resistant keratitis, necessitating microbial identification and drug susceptibility testing such as MALDI-TOF-MS.

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羊膜移植后丙基棒状杆菌细菌性角膜炎1例。

背景：羊膜移植（AMT）是一种相对安全且并发症少的手术。术后，患者使用局部抗菌滴眼液治疗。然而，即使使用抗菌药物也不能完全预防抗菌素耐药性角膜炎。本文报告一例与AMT相关的丙基棒状杆菌角膜炎。病例介绍：一名84岁女性患者因大疱性角膜病变接受AMT治疗，术后45天在移植的羊膜移植物上发生角膜炎并形成菌落。该菌落被刮擦、培养，并使用基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF-MS）鉴定为丙酸c。随后，局部治疗在缓解疼痛的同时改善了感染。结论：据我们所知，这是第一例与羊膜移植相关的丙膜性角膜炎。虽然AMT是一种相对安全且并发症少的手术，但需要仔细观察以诊断和治疗可能的术后感染。免疫抑制患者，包括amt后患者，可能患有抗菌素耐药性角膜炎，需要进行微生物鉴定和药敏试验，如MALDI-TOF-MS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Ophthalmology OPHTHALMOLOGY-

CiteScore

3.40

自引率

5.00%

发文量

441

审稿时长

6-12 weeks

期刊介绍： BMC Ophthalmology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of eye disorders, as well as related molecular genetics, pathophysiology, and epidemiology.