Relationship between neuron-specific enolase and swallowing dysfunction in patients with acute ischemic stroke: a single-center retrospective study.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

BMC Neurology Pub Date : 2025-05-27 DOI:10.1186/s12883-025-04236-y

Danyang Meng, Yanjing Lu, Ning Chen, Jie Pan, Bingtong Lin, Jin Hu

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引用次数: 0

Abstract

Objective: This study was aimed to investigate the relationship between neuron-specific enolase (NSE) and swallowing dysfunction in patients with acute ischemic stroke (AIS) and evaluate the impact of early enteral nutrition intervention on NSE levels.

Setting and participants: A retrospective study was conducted involving 445 AIS patients admitted to the neurology department of the Affiliated Hospital of Jiaxing University between September 2015 and August 2022. Data collected included gender, age, water-swallowing test (WST) score upon admission, and NSE examination results on admission, the 5th day, and the 10th day.

Results: Among 445 enrolled AIS patients, 42.0% (187/445) exhibited swallowing dysfunction. Key findings revealed: (1) Positive correlation between WST severity and serum NSE levels across all timepoints (P < 0.05). (2) Dysphagia patients demonstrated elevated NSE levels versus controls (P < 0.05). (3) Early enteral nutrition intervention (n = 98) significantly reduced NSE levels by day 10 compared to non-intervention group (P < 0.05), though no intergroup differences were observed at admission or day 5 (P > 0.05).

Conclusions: NSE measurement is a simple supplement to the WST. There existed a significant correlation between NSE and swallowing dysfunction, making NSE a potential preliminary screening indicator for evaluating in ischemic stroke patients. And early implementation of enteral nutrition intervention could effectively reduce NSE levels in patients with ischemic stroke.

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急性缺血性脑卒中患者神经元特异性烯醇化酶与吞咽功能障碍的关系：一项单中心回顾性研究

目的：探讨急性缺血性脑卒中（AIS）患者神经元特异性烯醇化酶（NSE）与吞咽功能障碍的关系，并评价早期肠内营养干预对NSE水平的影响。背景和参与者：对2015年9月至2022年8月在嘉兴学院附属医院神经内科住院的445例AIS患者进行回顾性研究。收集的数据包括性别、年龄、入院时的吞咽水测试（WST）评分、入院时、第5天和第10天的NSE检查结果。结果：445例AIS患者中，42.0%（187/445）出现吞咽功能障碍。(1) WST严重程度与血清NSE水平在各时间点呈显著正相关（P < 0.05）。结论：NSE测量是WST的简单补充。NSE与吞咽功能障碍之间存在显著相关性，可作为评估缺血性脑卒中患者的初步筛选指标。早期实施肠内营养干预可有效降低缺血性脑卒中患者NSE水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Neurology 医学-临床神经学

CiteScore

4.20

自引率

0.00%

发文量

428

审稿时长

3-8 weeks

期刊介绍： BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.