The Influence of Topiramate on Morphine Dependence in Mice.

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2025-05-16 DOI:10.3390/biom15050730

Adrian Pysiewicz, Antonina Mazur, Jolanta Kotlińska, Irena Baranowska-Bosiacka, Krzysztof Fronc, Małgorzata Łupina, Marta Kruk-Słomka, Joanna Listos

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Abstract

Topiramate evokes pharmacological activity via a blockade of voltage-dependent sodium channels, reduction in glutamate release, inhibition of AMPA receptors and kainate receptors, and potentiation of GABAergic neurotransmission. Therefore, it is used not only as an antiseizure drug but is also effective in migraine prophylaxis, cluster headaches, neuropathic pain, and alcohol dependence. The aim of this study was to investigate the effect of topiramate in morphine dependence in mice, particularly in terms of morphine tolerance, morphine withdrawal signs, and morphine sensitization. In these experiments, topiramate was administered both acutely and chronically. Topiramate significantly reduced the morphine tolerance in the hot-plate test and attenuated naloxone-induced morphine withdrawal signs. Its effect on morphine sensitization to the locomotor activity of mice was poor. The obtained results showed that topiramate might be an effective drug for reducing the physical symptoms of morphine dependence.

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托吡酯对小鼠吗啡依赖的影响。

托吡酯通过阻断电压依赖性钠通道、减少谷氨酸释放、抑制AMPA受体和kainate受体以及增强gaba能神经传递来唤起药理学活性。因此，它不仅被用作抗癫痫药物，而且对偏头痛预防、丛集性头痛、神经性疼痛和酒精依赖也有效。本研究的目的是研究托吡酯对吗啡依赖小鼠的影响，特别是在吗啡耐受性、吗啡戒断症状和吗啡致敏方面。在这些实验中，托吡酯被急性和慢性使用。托吡酯在热板试验中显著降低吗啡耐受性，减弱纳洛酮引起的吗啡戒断症状。其对小鼠运动活动的吗啡致敏作用较差。结果表明，托吡酯可能是减轻吗啡依赖躯体症状的有效药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.